Abcam, ab105597, Recombinant Human DECR1 protein

Size: 50µg / 250µg
Recombinant Human DECR1 protein is a Human Full Length protein, in the 35 to 335 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>90% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:SDS-PAGE, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q16698,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DECR1 also known as 24-Dienoyl-CoA Reductase 1 is an enzyme important in fatty acid metabolism. Its mass is approximately 35 kDa. It catalyzes the NADP-dependent reduction of 24-dienoyl-CoA to trans-enoyl-CoA an important step in the beta-oxidation of unsaturated fatty acids. DECR1 is expressed in many tissues but it shows especially high levels in the liver and heart. This expression pattern suggests its significant role in tissues where active lipid metabolism occurs.
Biological function summary
DECR1 supports the breakdown and energy release from unsaturated fatty acids. The enzymatic activity of DECR1 helps maintain cellular energy balance and overall metabolic homeostasis. It does not operate as part of a larger complex but it functions individually to catalyze reactions vital for energy production in cells. By converting dienoyl-CoA substrates into more readily oxidizable forms DECR1 facilitates energy production from dietary lipids and stored fat.
Pathways
DECR1 is integral to the beta-oxidation metabolic pathway which is important for energy production particularly in fasting conditions. This enzyme specifically acts on polyunsaturated fatty acids processing them within the mitochondrial matrix. DECR1's activity relates to similar enzymes like mitochondrial acyl-CoA dehydrogenase family members which work in tandem within the beta-oxidation cycle to ensure efficient fatty acid degradation.
DECR1 has significant connections to metabolic conditions particularly those involving lipid metabolism. DECR1 deficiency or mutations can lead to disorders such as 24-dienoyl-CoA reductase deficiency characterized by progressive encephalopathy and muscular weakness. DECR1's role in lipid metabolism also implicates it in conditions like non-alcoholic fatty liver disease (NAFLD). In NAFLD disrupted lipid metabolism links DECR1 to mitochondrial enzymes like CPT2 which also play roles in fatty acid oxidation.