Abcam, ab106231, Anti-LAF4 antibody

Size: 100µg
Rabbit Polyclonal LAF4 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human AFF3.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human AFF3. The exact immunogen used to generate this antibody is proprietary information.P51826

Properties and Storage Information:
Form-Lyophilized, Reconstitution-Reconstitute in 200 µL of water, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azide, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LAF4 also known as lymphoid nuclear protein related to AF4 is a transcription factor involved in gene regulation. It weighs approximately 110 kDa and acts primarily in the nucleus. LAF4 shows expression mainly in lymphoid tissues such as the spleen and thymus. It contains an amino acid sequence that facilitates interactions with other proteins allowing it to function effectively in transcriptional modulation.
Biological function summary
LAF4 influences the regulation of specific genes critical for immune function. It often participates in multiprotein complexes interacting with other cofactors that modify chromatin structure. LAF4's role in regulating transcription contributes to the control of cell differentiation and proliferation within the immune system. Additionally LAF4 is important for maintaining the balance between progenitor cell self-renewal and differentiation.
Pathways
LAF4 integrates into the Wnt signaling pathway which affects cell fate decisions migration and organogenesis. It interacts with proteins like beta-catenin and regulates downstream gene expression. LAF4 also plays a role in the Notch signaling pathway which has broad effects on development and immune responses. Cross-talk between LAF4 and other proteins in these pathways enables coordinated regulation of differentiation and development processes.
LAF4 correlates with certain cancers such as leukemia. Its dysregulation can lead to abnormal cell proliferation and survival often resulting from gene translocation events. LAF4 interacts with proteins like AF4 and is involved in leukemic transformations. Furthermore aberrant expression of LAF4 may link to autoimmune conditions given its regulatory role in the immune response and lymphoid tissue development.