Abcam, ab106412, Anti-Tspan-9 antibody

Size: 100µg
Rabbit Polyclonal Tspan-9 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human TSPAN9.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TSPAN9. The exact immunogen used to generate this antibody is proprietary information.O75954,
Specificity:At least four isoforms of Tspan-9 are known to exist; ab106412 will recognize all four.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Tspan-9 also known as Tetraspanin-9 is a protein involved in various cellular processes like cell adhesion proliferation and migration. This protein belongs to the tetraspanin superfamily characterized by four transmembrane domains. Tspan-9 has a molecular mass of approximately 26 kDa. Research shows that Tspan-9 is expressed in several tissues including the immune system's components such as leukocytes indicating its diverse role in immune functionality and cellular communication.
Biological function summary
Tspan-9 influences cell signaling pathways through interactions with other tetraspanins and membrane proteins. Tspan-9 associations with integrins facilitate the organization of signaling complexes that mediate cellular responses. It often forms complexes with proteins involved in maintaining the cell membrane's structural integrity. These interactions show its role in controlling cellular behavior relevant to growth and communication between cells.
Pathways
Tspan-9 plays a role in the regulation of integrin-mediated signaling and the PI3K/AKT signaling pathway. Tspan-9 interacts with proteins such as CD9 and integrins affecting pathways instrumental in cell survival and proliferation. These interactions contribute to cellular adhesion dynamics demonstrating Tspan-9's role in facilitating important cellular processes.
Alterations in Tspan-9 expression have a connection to certain cancer types. Specifically Tspan-9 modulates processes in tumor development and metastasis. Its interactions with proteins like CD9 have implications in cancer pathology affecting tumor growth and invasive potential. Additionally abnormalities in Tspan-9 function or regulation may link to immunological disorders reflecting its role in immune system modulation.