Abcam, ab106533, Anti-CXXC5 antibody

Size: 100µg
Rabbit Polyclonal CXXC5 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human CXXC5.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CXXC5. The exact immunogen used to generate this antibody is proprietary information.Q7LFL8

Product details:
Predicted to not cross-react with other CXXC protein family members.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-Up to 12 months, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CXXC5 also known as CXXC finger protein 5 is a DNA-binding protein with a molecular weight of approximately 35 kDa. This protein is expressed in various tissues including the brain and bone marrow. It functions mechanically by binding to unmethylated CpG dinucleotides influencing gene expression by affecting chromatin structure. Due to its DNA-binding ability CXXC5 can regulate transcription impacting various cellular processes.
Biological function summary
CXXC5 plays a role in the regulation of Wnt/β-catenin signaling pathway and is involved in controlling cellular proliferation and differentiation. It does not form part of a larger protein complex but it interacts with other proteins to exert its function. CXXC5 can act as a transcriptional regulator by recruiting other proteins to modify epigenetic marks and modulates pathways critical for development and disease.
Pathways
CXXC5 is involved in the Wnt/β-catenin signaling cascade a major pathway that regulates cell fate decisions migration and organogenesis. This protein bears relation to other pathway components such as β-catenin by interacting with them to convey signaling outcomes during cellular processes. In the bone it influences osteoblastic differentiation and bone formation making it an important component in skeletal development.
CXXC5 has been linked to conditions such as osteoporosis and certain types of cancer. In osteoporosis the altered function of CXXC5 affects bone density due to its role in bone anabolic responses with interactions with β-catenin being important. In cancer disruptions in CXXC5 expression or function can lead to uncontrolled cell proliferation and it is often examined in relation to tumor suppressor pathways highlighting its role in cellular growth control mechanisms.