Abcam, ab106568, Anti-SLC39A14/ZIP-14 antibody

Size: 100µg
Rabbit Polyclonal SLC39A14/ZIP-14 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse, Rat samples. Cited in 12 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human, Rat,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:At least three isoforms of SLC39A14/ZIP-14 are known to exist; this antibody will detect all isoforms.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-Up to 12 months, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SLC39A14 also known as ZIP14 is a transporter protein that facilitates the import of zinc manganese and iron into cells. It belongs to the Zrt/Irt-like protein (ZIP) family and weighs approximately 52 kDa. Researchers have observed its expression in various tissues including the liver pancreas and kidney. It can also be found in prostate tissue. Through its role in metal ion transport SLC39A14 plays a significant function in maintaining cellular trace metal homeostasis.
Biological function summary
The activity of SLC39A14 impacts numerous cellular processes by modulating intracellular metal concentrations. Its inclusion in the ZIP transporter family ties it to the regulation of metal ion balance critical for enzyme activities metabolic pathways and gene expression. While SLC39A14 does not form a complex with other proteins it operates in concert with other metal ion transporters ensuring proper ion distribution across cellular compartments.
Pathways
SLC39A14 influences metal transport pathways that are essential for maintaining metal homeostasis and signal transduction. It closely interacts with other metal transporters like SLC39A8 which cooperates to transport manganese and zinc. These pathways are essential components in ensuring proper enzyme functionality and cellular responses. SLC39A14’s role in import affects the PI3K-Akt signaling pathway by modulating the necessary metal cofactors for key enzymes.
Defects or imbalances in SLC39A14 function associate with disturbances in metal homeostasis leading to conditions like hypermanganesemia and liver pathology. Its activity affects the metabolism of manganese and aberrations can result in the accumulation of manganese impacting nervous system functions. SLC39A14 also connects to the protein ceruloplasmin in the context of iron metabolism disorders. Inefficient regulation or mutation of SLC39A14 can exacerbate disease progression in iron overload conditions highlighting its role as a potential therapeutic target.