Abcam, ab106686, Anti-LYRM2 antibody

Size: 100µg
Rabbit Polyclonal LYRM2 antibody. Suitable for ICC, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human LYRM2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human LYRM2. The exact immunogen used to generate this antibody is proprietary information.Q9NU23,
Specificity:ab106686 is predicted not to crossreact with other LYRM family members.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Affinity chromatography purified via peptide column., Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-Up to 12 months, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LYRM2 also known as lipoamide acyltransferase.using mitochondrial protein 2 is a small protein consisting of 111 amino acids with a mass of approximately 12 kDa. It is expressed primarily in the mitochondria of cells where it takes part in the formation and function of the mitochondrial RNA-processing enzyme complex. LYRM2 influences processes within mitochondria by ensuring proper enzymatic activity. The protein shows expression in various tissues which implicates its role in several cellular functions across different cell types.
Biological function summary
LYRM2 operates within the mitochondria where it links to enzymes associated with the synthesis and function of mitochondrial proteins. It is a member of the Lyr family of mitochondrial proteins and is part of a complex that includes mitochondrial acyltransferases. This association indicates an involvement with mitochondrial respiratory chain functions contributing to proper cellular energy metabolism. The protein stabilizes the acyltransferase components assisting in the regulation of mitochondrial enzyme activity.
Pathways
LYRM2 contributes significantly to the mitochondrial respiratory chain pathway and the regulation of mitochondrial protein synthesis. It interacts closely with other proteins like LYRM5 and components of the mitochondrial pyruvate dehydrogenase complex. LYRM2's association with these key proteins ensures efficient performance of the respiratory chain supporting ATP production. Its activity supports the overall energy balance within cells and affects cellular respiration efficiency.
LYRM2 has associations with mitochondrial disorders like Leigh syndrome and other conditions involving dysfunctional mitochondrial energy metabolism. Dysfunctional LYRM2 expression may result in impaired energy production which can exacerbate symptoms of mitochondrial diseases. The protein is connected to the disease mechanism through its interaction with critical proteins like NDUFS6 another mitochondrial complex component. Dysregulation of LYRM2 can impact cellular ATP levels contributing to the neurological and muscular symptoms observed in these disorders.