Abcam, ab106865, Recombinant E. coli MSRA protein

Size: 10µg
Recombinant E. coli MSRA protein is a Escherichia coli K-12 Full Length protein, in the 1 to 212 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>90% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:Mass Spec, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P0A744,
Animal free:No,
Carrier free:No,
Species:Escherichia coli K-12,
Storage buffer:pH: 8Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The 'MSRA' protein also known as Methionine Sulfoxide Reductase A is an enzyme that catalyzes the reduction of oxidized methionine residues within proteins. MSRA primarily operates by converting methionine sulfoxide back to methionine therefore playing a critical role in the repair of proteins that have been damaged by oxidative stress. The molecular weight of the MSRA protein typically falls around 25 kDa. Expression of MSRA is found in various tissues with notable levels in the liver kidney brain and heart.
Biological function summary
MSRA contributes to cellular defense against oxidative damage by restoring the normal function of proteins compromised by reactive oxygen species. This enzyme does not form part of a larger complex but acts independently on its substrate. It plays an important role in maintaining protein structure and function under stressful conditions such as during immune responses and aging.
Pathways
MSRA functions are important in the oxidative stress response and redox signaling pathways. It works alongside other antioxidant proteins like Methionine Sulfoxide Reductase B (MSRB) to maintain cellular homeostasis. The supportive roles within these pathways enhance the stability of cell environments protecting the cells from damage induced by external and internal oxidative agents.
MSRA is linked to conditions characterized by increased oxidative stress such as Alzheimer's disease and cardiovascular diseases. Reduced activity of MSRA correlates with higher oxidative stress levels leading to protein dysfunction within the brain and heart. The connections to these diseases often involve interactions with other oxidative stress-targeted proteins like superoxide dismutase and catalase highlighting MSRA's role in maintaining cellular integrity under pathophysiological conditions.