Abcam, ab106872, Recombinant Human TCTEX-1 protein

Size: 100µg
Recombinant Human TCTEX-1 protein is a Human Full Length protein, in the 1 to 113 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>95% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:Mass Spec, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P63172,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 30% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

Product details:
This product was previously labelled as DYNLT1

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TCTEX-1 also known as DYNLT1 or DLC1 is a component of the cytoplasmic dynein motor protein complex. It has a molecular mass of approximately 14 kDa. This protein localizes mainly to the cytoplasm and is expressed in a variety of tissues including the brain and kidneys. TCTEX-1 interacts with other proteins to facilitate cellular transport along microtubules which are essential components of the cell’s cytoskeleton aiding in maintaining cell shape and facilitating organelle movement.
Biological function summary
The role of TCTEX-1 involves the transport of vesicles and other cargo within cells using the dynein motor complex. This protein is a light chain component of the dynein which is a cytoplasmic motor protein complex responsible for retrograde transport movement along microtubules. It ensures the efficient transfer of intracellular organelles playing an essential role in cellular organization and function.
Pathways
TCTEX-1's involvement spans the intracellular trafficking and signaling pathways. It participates significantly in the endocytic pathway working closely with proteins like dynein heavy chain to mediate the efficient movement of endosomes. TCTEX-1 is also linked to the Wnt signaling pathway where its association with microtubule dynamics assists in cell signaling processes and influences cellular responses.
TCTEX-1 shows associations with neurodegenerative diseases such as Alzheimer's disease. Disruption in its function can lead to impaired axonal transport contributing to the pathological development of neurodegeneration. Additionally aberrant expression of TCTEX-1 is connected to certain types of renal cancer where interactions with proteins like BCL2L2 can influence cell survival and apoptosis pathways in tumor cells.