Abcam, ab106926, Anti-IREB2/IRP2 antibody

Size: 100µg
Goat Polyclonal IREB2/IRP2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Iron-responsive element-binding protein 2 aa 450-550.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human Iron-responsive element-binding protein 2 aa 450-550. The exact immunogen used to generate this antibody is proprietary information.P48200

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab106926 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Iron Regulatory Protein 2 (IREB2) also known as Iron Responsive Element Binding Protein 2 (IRP2) is an essential regulator of cellular iron homeostasis. IREB2 mechanically binds to iron-responsive elements (IREs) on mRNA controlling the post-transcriptional expression of target genes involved in iron metabolism. The protein has a molecular weight of approximately 105 kDa and is expressed in various tissues including the liver brain and pancreas. Its regulation is strongly controlled by iron availability with high iron levels leading to its degradation.
Biological function summary
IREB2 regulates the stability and translation of mRNAs encoding proteins linked to iron uptake storage and utilization. It plays an important role outside of a complex acting primarily on its own to bind transcripts that include ferritin and transferrin receptor mRNAs. Its activity increases under conditions of low iron availability promoting iron uptake and reducing iron sequestration to meet metabolic needs. Through these mechanisms IREB2 helps maintain iron supply for essential enzymes and cellular processes.
Pathways
IREB2 acts as a central player in the iron metabolism pathway influencing both iron import and storage. The pathways it participates in are essential for maintaining cellular and systemic iron balance. It works in coordination with IRP1 forming a regulatory network that adjusts iron homeostasis. Under varying iron concentrations IREB2 modulates expression of its target genes involved in iron transport and storage within the framework of the iron-sulfur cluster biosynthesis pathway.
Aberrant IREB2 activity links to neurodegenerative diseases such as Alzheimer's disease where iron dysregulation is often observed. Additionally IREB2 is associated with hemochromatosis a condition characterized by iron overload. In the context of these diseases IREB2 interacts with proteins such as APP in Alzheimer's and HFE in hemochromatosis influencing their role in disease progression and shedding light on potential therapeutic targets for maintaining iron balance.