Abcam, ab107611, Anti-NLRX1 antibody

Size: 100µg
Rabbit Polyclonal NLRX1 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse, Horse samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human NLRX1 aa 550-650.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Horse, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human NLRX1 aa 550-650. The exact immunogen used to generate this antibody is proprietary information.Q86UT6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-Up to 6 months, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NLRX1 also known as NOD-like receptor X1 is a protein that plays a role in the regulation of immune responses and mitochondrial function. It has a molecular mass of approximately 110 kDa. NLRX1 is widely expressed in various tissues but shows higher levels in immune-related organs such as the spleen and lymph nodes. This protein is part of the NOD-like receptor family known for sensing intracellular signals and initiating immune responses.
Biological function summary
NLRX1 regulates immune functions by modulating inflammatory responses and innate immunity. It interacts with other cellular components to form complexes that impact the production of reactive oxygen species and influence mitochondrial dynamics. NLRX1 promotes mitochondrial homeostasis and cellular metabolism acting as a negative regulator of the inflammatory pathway. This protein also participates in antiviral responses by influencing signaling pathways upon detection of viral infections.
Pathways
NLRX1 plays critical roles within the NF-kB signaling and mitochondrial response pathways. It interacts with NF-kB-related proteins affecting the transcription of pro-inflammatory genes. Additionally NLRX1 connects with mitochondrial antiviral signaling proteins impacting the cell's ability to respond to viral agents. These interplays illustrate NLRX1's involvement in maintaining cellular balance in response to stress or infection.
Multiple studies link NLRX1 to conditions such as inflammatory bowel disease and viral infections like influenza. Its regulatory role in NF-kB and mitochondrial pathways connects NLRX1 to other proteins like MAVS and TRAF6 influencing the severity and outcome of these diseases. Altered NLRX1 function can disrupt immune regulation and promote chronic inflammation highlighting its importance in disease pathogenesis and potential as a therapeutic target.