Abcam, ab108311, Anti-Transcription factor AP-2-alpha antibody [EPR2688(2)]

Size: 20µL / 100µL / 1mL
Anti-Transcription factor AP-2-alpha antibody [EPR2688(2)] (ab108311) is a rabbit monoclonal antibody detecting Transcription factor AP-2-alpha in Western Blot, Flow Cytometry (Intra), Flow Cytometry, IP, IHC-P, ICC/IF, ChIC/CUT&RUN sequencing . Suitable for Human, Mouse, Rat . - KO validated for confirmed specificity - Biophysical QC for unrivalled batch-batch consistency - Over 20 publications
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR2688(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, Flow Cyt (Intra), IHC-P, ICC/IF, ChIC/CUT&RUN-seq, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What is this antibody validated in?
Anti-Transcription factor AP-2-alpha antibody [EPR2688(2)] (ab108311) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) and ChIC/CUT&RUN sequencing in Human, Mouse, Rat samples.
What is the molecular weight of Transcription factor AP-2-alpha?
Anti-Transcription factor AP-2-alpha [EPR2688(2)] (ab108311) specifically detects a band for Transcription factor AP-2-alpha (UniProt: P05549) at a molecular weight of 48kDa.
Trusted by the scientific community
Anti-Transcription factor AP-2-alpha [EPR2688(2)] (ab108311) was first used in a scientific publication in 2011 and has been cited over 20 times in peer-reviewed journals.
Trial sizes available!
Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 20µl.
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Specificity confirmed
The specificity of Anti-Transcription factor AP-2-alpha antibody [EPR2688(2)] (ab108311) has been confirmed by Western blot testing in TFAP2A Knockout HAP1 cell line,
ab265122
Other related products
We have a range of other formats of antibody clone [EPR2688(2)] also available for your convenience: ab108311, Carrier free -
ab236043
, PE -
ab305403
, APC -
ab305404
, HRP -
ab305405
, Alkaline Phosphatase -
ab309016
, Alexa Fluor® 488 -
ab309663
, Alexa Fluor® 647 -
ab310026
, Alexa Fluor® 594 -
ab310404
, Alexa Fluor® 555 -
ab311931
, Alexa Fluor® 568 -
ab312402
, Alexa Fluor® 750 -
ab320892
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Transcription factor AP-2-alpha also known as TFAP2A or AP-2 is a protein acting as an important regulator in cellular processes. It weighs approximately 52 kDa. TFAP2A is known for its role in binding specific DNA sequences to regulate target gene transcription. It expresses highly in neural crest-derived tissues as well as in the placenta breast and skin. This transcription factor plays an essential role in embryonic development cell proliferation and differentiation.
Biological function summary
TFAP2A contributes significantly to the regulation of gene expression involved in essential developmental and cellular processes. It acts as part of a complex with other transcription factors allowing it to coordinate the expression of a variety of genes linked to cell growth and apoptosis. AP-2 also regulates genes involved in neural development and skin morphogenesis. Its interaction with other factors such as AP-2γ and AP-2B enhances its functionality indicating a complex mechanism of action.
Pathways
TFAP2A engages in critical signalling circuits such as the MAPK and Wnt pathways which are essential for cell cycle regulation and embryonic development. Within these pathways related proteins like AP-2γ and AP-594 interact with TFAP2A further illustrating its role in signal transduction. These relationships highlight the importance of TFAP2A in orchestrating cellular responses to growth signals and environmental cues.
TFAP2A has links to a range of pathological conditions including cancer and neural crest-related disorders. In melanoma for example TFAP2A's regulatory role affects genes associated with tumor growth and metastasis. The protein's interaction with other transcription factors like AP-647 may influence cancer progression and therapy response. Additionally the dysregulation of TFAP2A affects neural crest development potentially leading to congenital disorders. Understanding these interactions assists in unraveling the molecular basis of such diseases and informs therapeutic strategies.