Abcam, ab108340, Anti-ABI2 antibody [EPR3906]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ABI2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR3906,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ABI2 also known as Abl-Interactor 2 is a protein encoded by the ABI2 gene. It has a molecular mass of approximately 53 kDa. ABI2 functions as a regulator of actin cytoskeleton dynamics and participates in processes involving cell motility and morphology. This protein is mainly expressed in neuronal tissues and is found in the cytoplasm suggesting its involvement in intracellular signaling pathways where actin rearrangement is important.
Biological function summary
ABI2 impacts cellular functions by interacting with the WAVE (WASP-family verprolin-homologous) complex. This interaction facilitates the regulation of actin polymerization important for processes such as cell migration and synaptic plasticity. ABI2 through the WAVE complex plays a role in the formation of lamellipodia cellular protrusions important for movement. This regulation ensures that cells respond effectively to external stimuli by reorganizing their cytoskeleton.
Pathways
The protein contributes significantly to the regulation of the Rac1 signaling pathway important for cytoskeletal remodeling. ABI2 works closely with proteins such as NCK proteins and phosphoinositides that are part of this pathway. Furthermore ABI2 interacts with the PAK family of kinases influencing downstream signaling that controls cell cycle progression and survival. ABI2’s role in these pathways highlights its importance in maintaining cellular architecture and dynamics.
ABI2 is implicated in neurological conditions particularly Alzheimer's disease and schizophrenia. Its interaction with other proteins like APP (amyloid precursor protein) suggests a role in synaptic dysfunction seen in these disorders. ABI2’s involvement in actin dynamics connects it to synaptic defects that may contribute to cognitive impairments in Alzheimer's disease. Understanding ABI2’s function and interactions offers insights into therapeutic targets for these neurological conditions.