Abcam, ab108936, Anti-Ube2L3/UBCH7 antibody [EPR4368]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Ube2L3/UBCH7 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 5 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR4368,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Ube2L3 also known as UBCH7 is an E2 ubiquitin-conjugating enzyme with a molecular weight of approximately 21 kDa. This enzyme participates mechanically in the ubiquitination process where it transfers ubiquitin from an E1 activating enzyme to an E3 ligase mediating protein degradation through the proteasome. Ube2L3 is expressed ubiquitously in various tissues showing higher abundance in the brain heart and skeletal muscle.
Biological function summary
Ube2L3 plays essential roles in protein turnover and cell cycle regulation by functioning within multi-protein complexes. It helps facilitate the attachment of ubiquitin to specific target proteins marking them for degradation. These activities are important for maintaining protein homeostasis and regulation of cell division apoptosis and signal transduction. Ube2L3's role in these biological processes makes it an important component of cellular function and physiology.
Pathways
Ube2L3 is involved in the ubiquitin-proteasome pathway and is also associated with the NF-kB signaling pathway. Its function in these pathways highlights its role in regulating immune responses and inflammatory processes. Interaction with other proteins like E3 ligases including Parkin and Mdm2 shows its involvement in protein quality control and cellular stress responses. Ube2L3's modulation of these pathways is significant for proper cellular responses to environmental cues and stressors.
Ube2L3 associates with conditions like autoimmune diseases and certain cancers. Research links dysfunction in Ube2L3's activity to systemic lupus erythematosus (SLE) where immune regulation is disrupted. Furthermore studies indicate that alterations in its protein interactions particularly with E3 ligases such as Mdm2 might contribute to tumorigenesis by affecting p53 regulation. Understanding these connections helps in elucidating the roles of Ube2L3 in disease mechanisms and may support the development of targeted therapies.