Abcam, ab108975, Anti-RGS9 antibody [EPR2873]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal RGS9 antibody. Suitable for WB, ICC/IF, Flow Cyt (Intra) and reacts with Mouse, Rat, Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR2873,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, ICC/IF, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Regulator of G protein Signaling 9 or RGS9 plays an important role in the regulation of G protein-coupled receptor (GPCR) signaling pathways. RGS9 acts as a GTPase-activating protein (GAP) accelerating the deactivation of Gα subunits which helps terminate the signal transduction. This protein with a molecular mass of roughly 73 kDa is highly expressed in the brain especially in the striatum and in the retina. These tissues suggest its specialized involvement in visual and neurological functions.
Biological function summary
RGS9 functions as an important regulator within multiple signaling complexes. It associates with RGS9-binding protein (R9AP) and Gβ5 subunits to form larger complexes that enhance its activity. RGS9 regulates phototransduction in rod and cone photoreceptors by controlling the inactivation of transducin a heterotrimeric G protein involved in visual processing. This regulation ensures proper recovery of photoreceptors after light-induced activation maintaining visual acuity and stability.
Pathways
RGS9 is integral to visual signal transduction and dopaminergic signaling pathways. In the visual system it modulates the phototransduction cascade by interacting with transducin within the rod outer segment. Within dopamine pathways it affects signaling by modulating receptors like D2 dopamine receptors involving proteins such as Gαolf which mediates cAMP production. These interactions regulate neuronal responses to various stimuli impacting vision and limbic system functions.
RGS9 abnormalities relate to conditions like bradyopsia and drug addiction. Bradyopsia characterized by slow vision recovery after light exposure is linked to RGS9 mutations which disrupt normal photoreceptor recovery. In addiction altered RGS9 expression impacts dopamine signaling affecting addiction pathways with involvement of D2 dopamine receptors. Together these insights highlight RGS9's critical role in maintaining normal visual and neurological health.