Abcam, ab109024, Anti-GSC antibody [EPR4847]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal GSC antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR4847,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Negative WB result with mouse brain, heart, kidney and spleen tissue lysates, but there is a feedback this antibody detected mouse GSC with NMuMG (mouse mammary gland, normal epithelial) cell lysate. Other samples has not been tested.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Species reactivity
Rat: We have preliminary internal testing data to indicate this antibody may not react with this species.
Please
contact us
for more information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The biological target GSC also known as Goosecoid is a transcription factor with a molecular weight of approximately 28 kDa. It is expressed during early embryonic development and plays an important role in mesoderm patterning and differentiation. GSC is primarily found in specific regions such as the Spemann organizer in amphibians and the primitive streak in other vertebrates. The transcriptional activity of GSC is regulated through interactions with other proteins and signaling pathways which modulate its expression in these tissues.
Biological function summary
Goosecoid functions as a homeobox-containing transcription factor that regulates gene expression critical for embryogenesis. It forms part of transcriptional complexes that are involved in modulating the activity of target genes essential for morphogenetic movements. GSC activates or represses specific genes to control the cell fate and tissue patterning during development. It coordinates the expression of genes required for establishing body axis formation reflecting its role in orchestrating developmental processes.
Pathways
Goosecoid interacts with the Wnt and TGF-beta signaling pathways which are vital for early embryonic development. These pathways regulate the expression of several proteins such as beta-catenin and Smad proteins which are important for transducing signals that affect cell differentiation and migration. GSC’s involvement in these pathways highlights its role as a mediator of signals necessary for the coordination of complex developmental processes.
Disruptions in Goosecoid's expression or function are linked to congenital malformations such as craniofacial disorders and skeletal anomalies. Aberrant regulation of GSC may result in improper development leading to conditions such as Robinow syndrome where facial abnormalities and short stature are observed. Additionally alterations in the activity of proteins like BMP4 which interact with GSC further highlight the significance of this target in developmental pathologies.