Abcam, ab109241, Anti-GATA2 antibody [EPR2822(2)]

Size: 100µL / 1mL
Anti-GATA2 antibody [EPR2822(2)] (ab109241) is a rabbit monoclonal antibody detecting GATA2 in Western Blot, IP, ChIP . Suitable for Human, Mouse, Rat . - KO validated for confirmed specificity - Biophysical QC for unrivalled batch-batch consistency - Over 10 publications
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR2822(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IP, WB, ChIPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What is this antibody validated in?
Anti-GATA2 antibody [EPR2822(2)] (ab109241) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), ChIP in Human, Mouse, Rat samples.
What is the molecular weight of GATA2?
Anti-GATA2 [EPR2822(2)] (ab109241) specifically detects a band for GATA2 (UniProt: P23769) at a molecular weight of 51kDa.
Trusted by the scientific community
Anti-GATA2 [EPR2822(2)] (ab109241) was first used in a scientific publication in 2011 and has been cited over 10 times in peer-reviewed journals.
Trial sizes available!
Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.
Discover our selection of trial-size antibodies
Specificity confirmed
The specificity of Anti-GATA2 antibody [EPR2822(2)] (ab109241) has been confirmed by Western blot testing in GATA2 Knockout HEK-293 cells.
Other related products
We have a range of other formats of antibody clone [EPR2822(2)] also available for your convenience: ab109241, Carrier free -
ab239959
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GATA2 also known as GATA binding protein 2 is a transcription factor with a molecular mass of approximately 50 kDa. It plays an important mechanical role in regulating gene expression by binding to the DNA sequence "GATA". GATA2 is expressed in various tissues including hematopoietic cells the nervous system and the endothelium. It influences cell fate decisions impacting the development and function of multiple tissues and cell types.
Biological function summary
GATA2 governs hematopoiesis and vascular development. It operates within multiprotein complexes to control the transcription of genes necessary for the development and differentiation of hematopoietic stem cells. GATA2's presence aids in maintaining normal functions of these cells ensuring they proliferate and differentiate correctly. Its regulatory role extends to the vascular system where GATA2 controls endothelial cell function and blood vessel formation.
Pathways
Hematopoiesis and vascular development significantly involve GATA2. It participates in the Notch signaling pathway influencing cell differentiation and proliferation along with other transcription factors like GATA1 and FOG1. The pathway interplay facilitates normal blood cell production and proper vascularization emphasizing its important role in cellular development processes.
Defective GATA2 function links to immunodeficiency syndromes and acute myeloid leukemia (AML). Mutations in the GATA2 gene disrupt normal blood cell development often resulting in increased susceptibility to infections and hematologic malignancies. It interacts with proteins such as GATA1 in these pathological states highlighting its significance in both immune function and malignant transformation.