Abcam, ab109288, Anti-NETO2 antibody [EPR3497]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal NETO2 antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 6 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR3497,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.31% Sodium citrate, 0.175% Sodium chloride, 0.05% BSA, 0.0172% Ethylenediaminetetraacetic acid, disodium, dihydrate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NETO2 also known as Neuropilin and Tolloid-Like 2 is a transmembrane protein with a known mass of approximately 58 kDa. This protein functions mechanically as an auxiliary subunit for kainate receptors in the central nervous system. Researchers observe its expression predominantly in neurons but also in some other tissues. NETO2 alongside its variants impacts receptor functionality by modulating properties like receptor trafficking and kinetic attributes.
Biological function summary
The protein affects synaptic plasticity and neuronal communication. NETO2 forms part of a receptor complex with kainate receptors influencing synaptic transmission processes. This association is significant for excitatory neurotransmission which is important for learning and memory. Researchers emphasize the role of NETO2 in maintaining neuronal circuit efficiency and integrity.
Pathways
NETO2 involvement strongly ties to glutamatergic synapse pathways. It influences neuronal signaling through kainate receptor modulation which in turn affects calcium ion permeation. NETO2 also interacts with other proteins like GRIP1 (Glutamate Receptor Interacting Protein 1) within these pathways orchestrating synaptic stability and function.
Researchers link NETO2 alterations mainly to psychiatric disorders such as schizophrenia and neurodevelopmental disorders. In these contexts aberrant interactions with proteins like PSD95 (Postsynaptic Density Protein 95) could disrupt normal synaptic functioning. Researchers continue to investigate how dysregulation in NETO2 contributes to the molecular pathways underlying these conditions.