Abcam, ab109406, Anti-NeuroD2 antibody [EPR5135]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal NeuroD2 antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 8 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR5135,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NeuroD2 also known as Neuronal Differentiation 2 is a transcription factor involved in neurogenesis. It weighs approximately 40 kDa. This protein is part of the basic helix-loop-helix (bHLH) family which regulates gene expression. NeuroD2 is expressed mainly in the nervous system particularly in the developing brain and certain adult brain regions. Its expression pattern suggests an important role in neural development and maintenance.
Biological function summary
NeuroD2 influences neuronal differentiation and survival. It guides precursor cells toward a neuronal fate influencing neurogenesis and impacting brain structure. NeuroD2 does not form large protein complexes but interacts closely with other bHLH transcription factors. These interactions help regulate the transcription of genes necessary for the development and maturation of neurons.
Pathways
Transcription factors such as NeuroD2 play key roles in the neurogenesis pathway and the calcium signaling pathway. It operates in tandem with other proteins like NeuroD1 to effectively guide neural precursor cells toward differentiation into mature neurons. Through these pathways NeuroD2 helps regulate genes that are important for brain development and function.
Abnormal NeuroD2 expression relates to neurological conditions like autism spectrum disorders and certain types of epilepsy. Mutations or dysregulation in NeuroD2 can affect associated proteins like REST (RE1-Silencing Transcription factor) which plays a role in neuronal gene silencing. Understanding these connections provides insights into how NeuroD2 influences neural-related diseases and offers potential targets for therapeutic intervention.