Abcam, ab109597, Anti-PDE8A antibody

Size: 100µg
Rabbit Polyclonal PDE8A antibody. Suitable for IP, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human PDE8A.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PDE8A. The exact immunogen used to generate this antibody is proprietary information.O60658

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein PDE8A also known as phosphodiesterase 8A performs as an enzyme that hydrolyzes cyclic adenosine monophosphate (cAMP) to adenosine monophosphate (AMP). This action regulates the intracellular levels of cAMP an important second messenger in many signaling pathways. PDE8A has a molecular mass of approximately 100 kDa and is expressed mainly in endocrine tissues like the adrenal gland and thyroid as well as in specific immune cells.
Biological function summary
The regulatory function of PDE8A on cAMP levels impacts many processes including hormone secretion and immune responses. It often functions independently rather than as part of a complex but sometimes may interface with other proteins mediating these pathways. By controlling cAMP PDE8A influences various biological actions like glucose metabolism and T-cell activation.
Pathways
PDE8A activity connects to key signaling pathways such as the cAMP-dependent protein kinase (PKA) pathway where it modulates responses through cAMP degradation. In this pathway it interacts indirectly with proteins like CREB (cAMP response element-binding protein) affecting transcriptional activity that governs metabolic and immune responses. PDE8A also interfaces with other phosphodiesterases which further modulate the cAMP levels in the cell.
Alterations in PDE8A levels or function have links to adrenal hyperplasia where abnormal hormone production affects body processes. PDE8A and its regulatory role in cAMP balance also relate to immune function disorders as improper T-cell activation leads to autoimmune conditions. These associations illustrate PDE8A's involvement with broader protein interactions including those regulating endocrine and immune homeostasis.