Abcam, ab109940, Recombinant Human DRG1 protein

Size: 50µg / 250µg
Recombinant Human DRG1 protein is a Human Full Length protein, in the 1 to 367 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>85% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:Mass Spec, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9Y295,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 30% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.0292% EDTA, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The DRG1 protein also known as Developmentally Regulated GTP-binding protein 1 is an important player in cellular functions. This highly conserved protein has a mass of approximately 42 kDa and is expressed in various tissues including the brain and testis indicating its essential role in different biological processes. It contains GTP-binding motifs important for its activity which allows the protein to interact with other molecular partners in the cell facilitating its participation in cellular events.
Biological function summary
DRG1 engages in several critical cellular processes beyond its mechanical functions. One of its notable roles involves contributions to ribosome biogenesis although it does not form a permanent complex with the ribosome. The protein supports cellular growth and division highlighting its potential in affecting cell cycle regulation. DRG1 associates transiently with other proteins allowing it to influence a range of biological functions including cellular growth signaling pathways.
Pathways
Research indicates that DRG1 links to important regulatory networks such as the Ras signaling and translational control pathways. Within these pathways DRG1 interacts with proteins like eukaryotic initiation factors which are important for translation regulation. This interaction plays a role in coordinating protein synthesis which supports overall cellular growth and response to environmental cues. Understanding its place in these pathways sheds light on how cells control protein production and growth.
Studies suggest DRG1's involvement in cancer and neurological disorders. In certain cancers altered expression of DRG1 correlates with tumor progression implicating its role in cell proliferation and survival mechanisms. Additionally DRG1 has connections to neurodegenerative disorders potentially through interactions with tau protein which is associated with abnormal protein deposits in the brain. The protein’s link to these diseases highlights the need for further research into its functional mechanisms and potential as a therapeutic target.