Abcam, ab109961, Recombinant Human SULT1A2 protein

Size: 100µg
Recombinant Human SULT1A2 protein is a Human Full Length protein, in the 1 to 295 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>95% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:SDS-PAGE, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P50226,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.058% Sodium chloride, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SULT1A2 also known as Sulfotransferase Family 1A Member 2 is an enzyme involved in the sulfonation pathway. This enzyme has a molecular weight of approximately 34 kDa and is expressed mainly in the liver as well as other tissues like the intestines and lungs. Mechanically SULT1A2 functions by transferring sulfate groups to various substrates including hormones drugs and xenobiotic compounds. This enzymatic activity plays an important role in increasing the solubility of these molecules facilitating their excretion from the body.
Biological function summary
The sulfonation activity of SULT1A2 contributes to the regulation and metabolism of hormones and drugs. It is not part of a larger complex but works independently to modulate hormone activity and detoxify xenobiotics. This enzyme's ability to modify the biochemical properties of its substrates is essential in cellular regulation and homeostasis impacting physiological processes in humans.
Pathways
The activity of SULT1A2 is involved in the metabolism and detoxification pathways. It closely interacts with other phase II detoxification enzymes such as those in the UDP-glucuronosyltransferase family. Through these pathways SULT1A2 helps transform hydrophobic compounds into more hydrophilic forms aiding in their elimination from the organism. The enzyme's role in hormone homeostasis connects it to pathways involving hormone regulation and action.
SULT1A2 has links to certain cancers and drug metabolism disorders. In cancers altered expression levels of SULT1A2 may affect the balance of hormones potentially contributing to oncogenesis. It has also been noted in disorders of drug metabolism where malfunction of SULT1A2 can impact the efficacy and toxicity of administered medications. The enzyme interacts with cytochrome P450 family proteins which play roles in the metabolic pathways of both drugs and endogenous compounds.