Abcam, ab110003, Anti-LDB3 antibody

Size: 50µg
Goat Polyclonal LDB3 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human LDB3 aa 250-300.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human LDB3 aa 250-300. The exact immunogen used to generate this antibody is proprietary information.O75112

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LDB3 also known as LIM domain-binding protein 3 or ZASP plays a mechanical role in muscle function. It is a protein of approximately 80-110 kDa depending on its various isoforms. LDB3 is mainly expressed in cardiac and skeletal muscle tissues where it localizes at the Z-lines within the sarcomeres. It interacts with other structural proteins to provide stability impacting muscle contraction and integrity.
Biological function summary
In the context of muscle function LDB3 is an essential component of the sarcomere where it participates in a protein complex that includes alpha-actinin. This association helps maintain the structural organization of muscles and supports the force transmission required for muscle contractility. Furthermore LDB3 regulates protein-protein interactions contributing to muscle architecture and signaling pathways.
Pathways
The LDB3 protein operates in the context of muscle cell signaling and structural pathways. LDB3 connects to the integrin-linked kinase (ILK) pathway which influences cell survival and muscle differentiation. It also plays a role in the actin cytoskeleton pathway where it associates with proteins such as filamin and myotilin supporting muscle cell stability and dynamics.
LDB3 has significant connections to cardiomyopathy and myofibrillar myopathy. Mutations or deficiencies in LDB3 can lead to these conditions affecting muscle function and leading to symptoms such as muscle weakness or cardiac complications. LDB3 disorders can involve interactions with proteins like desmin which when mutated exacerbate muscle tissue disorganization and disease progression.