Abcam, ab110272, Anti-COX4, mitochondrial antibody [1A12A12]

Size: 100µg
Mouse Monoclonal COX4, mitochondrial antibody. Suitable for WB and reacts with Saccharomyces cerevisiae samples. Cited in 28 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:1A12A12,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:No,
Reacts with:Saccharomyces cerevisiae,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
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Properties and Storage Information:
Form-Liquid, Purity-IgG fraction, Purification notes-Near homogeneity as judged by SDS-PAGE. ab110272 was produced in vitro using hybridomas grown in serum-free medium, and then purified by biochemical fractionation., Storage buffer-pH: 7.5Preservative: 0.02% Sodium azideConstituents: HEPES buffered saline, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
COX4 also known as cytochrome c oxidase subunit IV is a component of the mitochondrial respiratory chain. It has an approximate molecular weight of 17 kDa. COX4 is expressed in high levels in tissues with abundant energy requirements such as heart muscle and brain. This protein is part of the cytochrome c oxidase (complex IV) the last enzyme in the mitochondrial electron transport chain which plays an important role in cellular respiration.
Biological function summary
The cytochrome c oxidase complex facilitates the transfer of electrons from cytochrome c to oxygen ultimately generating water. This process contributes to the proton gradient across the mitochondrial membrane necessary for ATP synthesis. COX4 serves as a regulatory subunit that can influence the efficiency of the electron transfer process. This complex is vital for maintaining the balance of energy production in cells and has a role in adaptive responses to varying energy demands.
Pathways
COX4 functions in the oxidative phosphorylation pathway which is critical for ATP production in eukaryotic cells. This pathway includes several protein complexes with COX4 being a part of the terminal complex IV. It interacts with other proteins such as cytochrome c and ATP synthase linking electron transport to ATP production. In turn this pathway supports various biological functions and maintains cellular energy homeostasis.
Dysfunctional COX4 is associated with mitochondrial diseases that often lead to compromised energy production. Conditions such as mitochondrial myopathy and cytochrome c oxidase deficiency have been linked to functional anomalies in COX4. These disorders can affect muscles and neural tissues leading to symptoms such as muscle weakness and neurological impairments. COX4 acts with proteins like cytochrome c and other subunits of the cytochrome c oxidase complex in these disease mechanisms influencing the severity and progression of these conditions.