Abcam, ab111121, Anti-ALK-7 antibody

Size: 100µg
Rabbit Polyclonal ALK-7 antibody. Suitable for IHC-P, ICC/IF and reacts with Human, African green monkey samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human ACVR1C.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, African green monkey,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ACVR1C. The exact immunogen used to generate this antibody is proprietary information.Q8NER5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab111121 was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ALK-7 also known as Activin receptor-like kinase 7 is a type I receptor serine/threonine kinase. It has a molecular mass of approximately 58 kDa. ALK-7 is primarily expressed in the central nervous system pancreatic islets and adipose tissue. This protein plays a mechanical role as a receptor that binds to ligands like Nodal which initiates signaling through phosphorylation events essential for cellular communication and regulation.
Biological function summary
ALK-7 participates in the regulation of metabolic processes. It functions by forming a receptor complex with type II receptors upon ligand binding transmitting signals that modulate cellular responses. ALK-7's signaling is important in maintaining glucose homeostasis and energy balance within tissues. Additionally the activity of ALK-7 influences the differentiation of neural cells and the development of adipose tissue illustrating its multifaceted biological roles.
Pathways
The signaling of ALK-7 integrates into the TGF-beta/Activin signaling pathway and the Nodal signaling pathway. Within these pathways it associates functionally with proteins such as SMAD2/3 which facilitate the transmission of extracellular signals to the nucleus resulting in gene expression changes. These pathways are significant for developmental processes and cellular metabolism regulation where ALK-7 contributes to signal transduction necessary for physiological adaptations.
ALK-7 has associations with metabolic syndromes like type 2 diabetes and obesity. Altered ALK-7 signaling affects insulin sensitivity and glucose metabolism linking it to the pathophysiology of these conditions. Furthermore its interaction with Nodal and other factors in related pathways suggests a potential therapeutic target for mitigating metabolic dysfunctions associated with these disorders.