Abcam, ab111582, Anti-Grainyhead-like protein 1 homolog antibody

Size: 50µL
Rabbit Polyclonal Grainyhead-like protein 1 homolog antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human GRHL1 aa 1-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human GRHL1 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.Q9NZI5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab111582 is purified by antigen affinity chromatography., Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Grainyhead-like protein 1 homolog known as GRHL1 plays an important role in transcription regulation. It functions as a transcription factor binding to DNA and influencing gene expression. This protein has a molecular mass of approximately 74 kDa and is expressed in various tissues with a strong presence in the skin and other epithelial tissues. GRHL1 is important for maintaining the integrity of epithelial cells which form protective barriers in the body.
Biological function summary
GRHL1 controls processes related to cell differentiation adhesion and proliferation. It does not function in isolation but rather forms part of transcriptional complexes that modify the expression of target genes. By doing so GRHL1 helps regulate the development and maintenance of epithelial structures. Its activity supports the transcription of genes necessary for the formation of cell junctions and maintenance of epithelial morphogenesis.
Pathways
GRHL1 integrates into several key biological processes notably the Wnt signaling pathway and cell adhesion pathways. In the Wnt pathway GRHL1 interacts with known signaling regulators like β-catenin to influence cell fate decisions and tissue homeostasis. GRHL1's role in cell adhesion pathways helps modulate interactions between epithelial cells working with proteins such as E-cadherin to ensure proper adhesive functions and cellular organization.
GRHL1 has associations with skin conditions and some types of cancer. Altered expression or mutations in GRHL1 and its pathways can contribute to disorders like ectodermal dysplasia a condition affecting the development of skin hair and nails. Additionally changes in GRHL1 levels and its activity have links to tumorigenesis in epithelial tissues often in conjunction with disrupted E-cadherin functions. This makes it a potential marker or therapeutic target in certain epithelial-related conditions.