Abcam, ab111599, Anti-Keratin 36 antibody

Size: 50µL
Rabbit Polyclonal Keratin 36 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human KRT36 aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human KRT36 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.O76013

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab111599 is purified by antigen affinity chromatography., Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Keratin 36 also known as KRT36 or K6HF is a type I keratin protein within the keratin family. The protein has a mass of approximately 50 kDa. This protein primarily expresses in hair follicles particularly in the inner root sheath and the hair shaft cortex. Keratin 36 contributes to the mechanical stability and integrity of hair fibers assisting in forming and maintaining the strength and resilience of the hair structure.
Biological function summary
Keratin 36 serves an important role in the structural framework of epithelial cells specifically those contributing to keratinocyte function and hair formation. It forms intermediate filaments as part of a larger keratin complex interacting with other keratins such as type II hard keratins in hair and nails. These interactions help establish the strong and insoluble nature of the protective barriers where keratin is present.
Pathways
Keratin 36 participates in intricate signaling related to hair follicle morphogenesis and differentiation. It is involved in the epithelial structural complex working alongside pathways such as the Wnt signaling pathway and the epidermal growth factor (EGF) signaling pathway. Related proteins like Keratin 35 and Keratin 85 also play essential roles in these pathways further integrating with the processes governing hair and skin tissue formation.
Keratin 36 mutations or dysregulation link to conditions like hair disorders and keratoderma. Specifically hereditary conditions such as monilethrix characterized by brittle beaded hair show associations with alterations in keratin expression patterns. Keratin 36 interacts with proteins like Filaggrin and Loricrin in these contexts which are also involved in related structural disorders of the skin.