Abcam, ab112043, Anti-EPC1 antibody

Size: 100µg
Rabbit Polyclonal EPC1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human EPC1 aa 300-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human EPC1 aa 300-400. The exact immunogen used to generate this antibody is proprietary information.Q9H2F5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
EPC1 also called Enhancer of Polycomb homolog 1 is a nuclear protein with a mass of approximately 89 kDa. It plays a role in chromatin remodeling as part of the NuA4 histone acetyltransferase complex. EPC1 is expressed in various tissues with notable expression in embryonic tissues and somatic cells undergoing differentiation. There is significant involvement of EPC1 in transcriptional regulation through modification of chromatin structure.
Biological function summary
As a component of the NuA4 complex EPC1 contributes to the acetylation of histones impacting gene expression. This complex is involved in chromatin modification and facilitates transcriptional activation of genes related to cell cycle progression DNA repair and development. By influencing these vital processes EPC1 affects cell proliferation and differentiation highlighting its role in maintaining genomic stability and cellular integrity.
Pathways
EPC1 engages in key signaling pathways such as the Notch signaling pathway and the DNA damage response pathway. These pathways are critical in regulating cell fate decisions and maintaining genomic stability. EPC1 interacts with proteins like EP400 which is part of the same complex as well as other transcription factors and co-factors that mediate its effects on gene expression and chromatin dynamics.
EPC1 shows association with certain cancers particularly those with dysregulated chromatin structures and developmental disorders. Aberrant function or expression of EPC1 may contribute to tumorigenesis especially in hematological malignancies. Mutations or dysregulation in associated proteins like EP400 and others within the NuA4 complex can further impact disease progression implicating EPC1 as a potential target for therapeutic intervention in these contexts.