Abcam, ab112055, Anti-YL1 antibody

Size: 100µg
Rabbit Polyclonal YL1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human VPS72 aa 50-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human VPS72 aa 50-100. The exact immunogen used to generate this antibody is proprietary information.Q15906

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein YL1 also known as Tyrosine-tubulin ligase-like family member 5 (TUBE1) plays an important role in regulating microtubule dynamics. YL1 has a molecular mass of approximately 14 kDa. It predominantly expresses in cells with high microtubule activity such as neural tissues and dividing cells. The protein actively binds to tubulin which is an essential component of the microtubule network within the cell. This binding modifies tubulin dynamics impacting cell shape and intracellular transport.
Biological function summary
YL1 influences the stability and organization of microtubules within the cellular cytoskeleton. It is part of a functional complex that involves tubulin which facilitates proper microtubule attachment and detachment during cell division. By modulating microtubule filament properties YL1 ensures accurate chromosome segregation contributing to the faithful completion of mitosis and meiosis.
Pathways
YL1 takes part in important cellular processes related to the regulation of cytoskeleton dynamics and cell cycle progression. It actively participates in the mitotic spindle assembly pathway where it cooperates with proteins such as TPX2 and Aurora A kinase. Additionally YL1 associates with the Rho GTPase signaling pathway which affects cytoskeletal reorganization and cell morphology linking to proteins like RhoA and Rac1 vital for actin and microtubule coordination.
YL1 has shown implications in conditions such as cancer and neurodegenerative diseases. Dysregulation of YL1 and associated pathways may contribute to uncontrolled cell proliferation and tumor development with connections to proteins like p53 and BRCA1. In neurodegenerative disorders abnormal YL1 function might affect neuronal microtubule integrity associating it with proteins such as tau which is involved in tauopathies like Alzheimer's disease.