Abcam, ab113531, Anti-FPR1 antibody

Size: 50µL
Rabbit Polyclonal FPR1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 16 publications. Immunogen corresponding to Synthetic Peptide within Human fMet-Leu-Phe receptor conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human fMet-Leu-Phe receptor conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P21462

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FPR1 also known as fMet-Leu-Phe receptor (fMLP receptor) is a G-protein coupled receptor with a molecular mass of approximately 38 kDa. It primarily expresses on the surface of myeloid cells like neutrophils monocytes and macrophages. FPR1 mediates responses to chemotactic factors guiding immune cells to sites of infection or inflammation by detecting formyl peptides from bacterial and mitochondrial origins.
Biological function summary
FPR1 plays an important role in initiating and regulating innate immune responses. It is not part of a complex but functions through association with G-proteins which activate intracellular signaling cascades. Its activation leads to rapid cellular responses such as chemotaxis superoxide production and degranulation which are essential for effective pathogen clearance by the immune system.
Pathways
FPR1 involvement in chemotaxis and MAP kinase signaling highlights its importance in immune surveillance. It integrates signals from bacteria-derived formylated peptides linking the external chemotactic cues to the internal migratory response of leukocytes. Other proteins like the chemokine CXC receptor family operate in complementary pathways to FPR1 collectively orchestrating immune trafficking and activation.
Defective FPR1 function is implicated in chronic inflammatory conditions and impaired host defense mechanisms such as systemic lupus erythematosus (SLE) and certain bacterial infections. In SLE altered FPR1 activity disrupts normal immune response contributing to disease persistence. FPR1's interaction with proteins like CD14 further highlights its role in modulating inflammatory responses relevant to these conditions.