Abcam, ab114875, Recombinant Human SMARCA6 protein

Size: 10µg
Recombinant Human SMARCA6 protein is a Human Full Length protein, in the 1 to 348 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:SDS-PAGE, ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9NRZ9,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.3% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SMARCA6 also known as SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6 is a protein with a molecular weight of approximately 170 kDa. It functions as an ATPase and is an important component of chromatin remodeling complexes. SMARCA6 plays a role in modifying chromatin structure through ATP hydrolysis which influences gene expression. This protein is expressed in various tissues and its expression can be detected across different cell types including those involved in blood functions.
Biological function summary
SMARCA6 influences gene expression by modifying the chromatin structure which allows transcription factors to access DNA. It is a part of the SWI/SNF chromatin remodeling complex critical for regulating a wide range of genes involved in development and cell cycle. Through the remodeling of chromatin SMARCA6 controls access to specific genomic regions and modulates transcriptional activation or repression therefore influencing cellular differentiation and proliferation.
Pathways
SMARCA6 participates in pathways involved in chromatin organization and gene regulation. It engages in the Wnt signaling pathway interacting with proteins such as BAF155 and BAF170 to modulate transcriptional outcomes. SMARCA6's activity in these pathways is essential for cellular processes impacting how cells respond to growth signals and maintain homeostasis.
Aberrations in SMARCA6 function or expression can lead to complications such as cancer and neurodevelopmental disorders. It has been linked to leukemia where chromatin remodeling anomalies disrupt normal gene expression patterns. In such contexts SMARCA6 interacts with proteins like BAF57 affecting the regulation of oncogenes and tumor suppressors. Altered SMARCA6 activity in these diseases highlights its role in maintaining genomic stability and proper cell function.