Abcam, ab115607, Anti-KCC1 antibody

Size: 50µg
Goat Polyclonal KCC1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SLC12A4 aa 950-1050.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SLC12A4 aa 950-1050. The exact immunogen used to generate this antibody is proprietary information.Q9UP95

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 99% Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
KCC1 also known as SLC12A4 is a member of the K-Cl cotransporter family. It mechanically transports potassium (K+) and chloride (Cl-) ions across the cell membrane. This transport occurs through an electroneutral process that plays an important role in maintaining cellular ionic homeostasis. KCC1 is expressed widely in many tissues including the kidney brain and heart. The molecular mass of KCC1 is approximately 120 kDa. Its expression in diverse tissues indicates its importance in various physiological processes.
Biological function summary
KCC1 regulates the cell volume and chloride ion concentration. It functions as a part of a complex that balances osmotic pressure within cells influencing processes like neuronal signaling and cell proliferation. In neurons KCC1 helps maintain the resting membrane potential which is essential for proper signaling. Its activity in the kidney regulates electrolyte balance contributing to normal renal function. The role of KCC1 in cell volume regulation highlights its involvement in fundamental cellular processes.
Pathways
KCC1 plays roles in the WNK-SPAK/OSR1 pathway an important element in ion homeostasis. This pathway influences the regulation of electrolyte transport in epithelial cells. KCC1 interacts with proteins like WNK kinases and SPAK which modulate its activity in response to changes in cellular hydration status. The crosstalk and regulation within these pathways ensure the tight control of ion transport necessary for proper cellular environment maintenance.
KCC1 has links to hypertension and neurological disorders. Its dysregulation impacts blood pressure through its effects on renal electrolyte handling suggesting a connection with hypertension. Additionally KCC1's role in neuronal ion balance indicates potential involvement in epilepsy. In epilepsy altered KCC1 function can influence the excitability of neurons potentially relating to seizure activity. Interactions with proteins such as WNK1 highlight the role of KCC1 in these pathological conditions.