Abcam, ab115791, Anti-Surfactant Protein A/PSAP antibody

Size: 100µg
Rabbit Polyclonal Surfactant Protein A/PSAP antibody. Suitable for IHC-P, WB and reacts with Mouse, Rat samples. Cited in 18 publications. Immunogen corresponding to Synthetic Peptide within Mouse Sftpa1 aa 200 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Mouse Sftpa1 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P35242

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate)Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Surfactant Protein A also known as PSAP is an important component found in the lungs. It is a protein approximately 35-40 kDa in size. Surfactant Protein A is predominantly expressed in the alveolar type II cells and Clara cells within the respiratory tract. This protein plays a significant role in lung function helping to maintain the surface tension of the alveoli to prevent collapse and to assist in host defense mechanisms as part of the lung surfactant system.
Biological function summary
Surfactant Protein A contributes to processes involving immune defense and inflammation control. It forms part of a larger surfactant complex and its main function is to bind and clear pathogens and allergens from the pulmonary system. The protein thereby plays an important role in recognizing foreign bodies promoting phagocytosis by macrophages and modulating inflammatory responses which is important for maintaining lung health and preventing infections.
Pathways
Surfactant Protein A interacts within immune signaling networks notably the lectin and complement activation pathways. These pathways facilitate the identification and clearance of pathogens. The protein stands in close relation to other members of the surfactant protein family such as Surfactant Protein D enhancing its functional scope in pulmonary immunity and host defense.
The malfunction or altered expression of Surfactant Protein A associates with respiratory conditions including pulmonary fibrosis and respiratory distress syndrome. Deficiencies or anomalies in this protein can also impact immune responses contributing to chronic obstructive pulmonary disease (COPD) by interacting with related proteins like Surfactant Protein B which is also important in surfactant function and maintenance of alveolar stability. Understanding these connections can aid in developing treatments targeting these pathways and disease mechanisms.