Abcam, ab116155, Recombinant Human DHRS4 protein

Size: 10µg
Recombinant Human DHRS4 protein is a Human Full Length protein, in the 1 to 278 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>85% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:SDS-PAGE, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9BTZ2,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.5Constituents: 20% Glycerol (glycerin, glycerine), 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DHRS4 also known as Dehydrogenase/Reductase SDR Family Member 4 plays an important role in metabolic processes. This enzyme with a mass of approximately 36 kDa primarily engages in oxidoreductive activities affecting the metabolism of steroids and retinoids. Its expression is particularly high in the liver but can also be found in lung and kidney tissues. The protein facilitates the conversion of aldehydes and ketones into their corresponding alcohols influencing metabolic pathways significantly.
Biological function summary
The dehydrogenase/reductase family member 4 interacts with multiple substrates impacting cellular redox status. This protein is not known to be part of a larger complex but interacts dynamically with other molecules within the cell. It contributes notably to the synthesis and breakdown of retinoic acids which are essential for cellular differentiation and growth. By managing retinoic acid levels DHRS4 helps regulate gene expression and various cellular responses.
Pathways
DHRS4 integrates into the retinoid metabolism and transport pathway as well as the steroid hormone biosynthesis pathway. It works alongside proteins such as retinol-binding protein 4 (RBP4) in retinoid metabolism influencing the availability and activity of retinoic acids. The interplay of DHRS4 with these pathways indicates its role in maintaining homeostasis of important biochemical processes in the body affecting energy metabolism and hormone regulation.
DHRS4 has been linked to metabolic disorders including hepatic diseases due to its role in lipid metabolism. Alterations in DHRS4 expression or function may contribute to fatty liver disease through disrupted retinoid processing. Additionally its involvement in steroid metabolism indicates possible connections to endocrine disorders occasionally interacting with cytochrome P450 enzymes which further impacts hormone synthesis and balance. The enzyme's importance in managing metabolic activities highlights its relevance in disease contexts.