Abcam, ab116204, Recombinant Human PTPMT1 protein

Size: 100µg
Recombinant Human PTPMT1 protein is a Human Full Length protein, in the 28 to 201 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>95% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:SDS-PAGE, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q8WUK0,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PTPMT1 also known as protein tyrosine phosphatase mitochondrial 1 has a molecular mass of approximately 23 kDa. This protein is a unique phosphatase localized to the mitochondria. It specifically dephosphorylates phosphatidylinositol phosphates and plays a critical role in mitochondrial function. PTPMT1 is expressed highly in tissues with significant energy demands like the heart and skeletal muscle suggesting its role in energy metabolism.
Biological function summary
A phosphatase that is involved in important tasks within the mitochondria PTPMT1 contributes significantly to the regulation of mitochondrial metabolism. It removes phosphate groups from target substrates which is essential for the biosynthesis of cardiolipin an important lipid in mitochondrial membrane composition. Although not formally part of a large complex it interacts closely with other mitochondrial enzymes to maintain lipid homeostasis.
Pathways
Lipid metabolism and insulin signaling both involve PTPMT1. It mediates its actions through the biosynthesis of phosphatidylinositol derivatives that influence the insulin signaling pathway. It has a connection with the PI3K/Akt signaling cascade affecting the actions of proteins such as Akt and PDK1 which play integral roles in cellular energy balance and glucose homeostasis.
Improper PTPMT1 function relates closely to metabolic disorders particularly diabetes mellitus. PTPMT1 activity affects insulin signaling and its dysregulation contributes to insulin resistance. There is also an association with mitochondrial dysfunction which may lead to neurodegenerative disorders. In these contexts PTPMT1's interaction with proteins like insulin receptor substrate (IRS) can provide avenues to study therapeutic targets for related diseases.