Abcam, ab116205, Recombinant Human RAB2B protein

Size: 100µg
Recombinant Human RAB2B protein is a Human Full Length protein, in the 1 to 216 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>95% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:Mass Spec, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q8WUD1,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RAB2B also known as Ras-related protein Rab-2B is a small GTPase of the Rab family with a molecular mass of approximately 23 kDa. This protein plays a significant role in regulating intracellular vesicle trafficking specifically involved in the movement between the endoplasmic reticulum and the Golgi apparatus. RAB2B is widely expressed in various tissues with higher levels in heart skeletal muscle and kidney indicating its importance in those organs.
Biological function summary
Small GTPases like RAB2B act as molecular switches cycling between an inactive GDP-bound form and an active GTP-bound form. This mechanism allows RAB2B to regulate membrane trafficking within the cell. RAB2B is also part of a larger protein complex that includes other Rab GTPases and effector proteins coordinating the direction and delivery of transport vesicles. This regulation ensures the correct sorting and modification of proteins within cells which is important for cellular function and growth.
Pathways
Studies show RAB2B is integral to the COPI and COPII vesicular transport pathways which are vital for proper protein processing and degradation. These pathways involve a network of proteins including RAB1 and in particular RAB6 which highlight its role in mediating transport from the ER to the Golgi apparatus and in intra-Golgi traffic. These interactions emphasize the importance of RAB2B in maintaining cellular homeostasis and operation of secretory pathways efficiently.
RAB2B and its functional impairments have connections to neurological disorders and certain cancers. Abnormal RAB2B expression or mutations may lead to neurodegenerative diseases through disrupted protein processing or degradation affecting neuronal survival. Furthermore RAB2B is linked to cancer progression where alterations in vesicle trafficking pathways might contribute to uncontrolled cell proliferation. The involvement of RAB1 and RAB6 in similar pathways and diseases further supports the role of RAB2B in the pathology of these conditions.