Abcam, ab116648, Anti-Estradiol antibody [AB4.2]

Size: 100µg
Mouse Monoclonal Estradiol antibody. Suitable for IP, ELISA, RIA and reacts with Chemical samples. Cited in 1 publication. Immunogen corresponding to Chemical / Small Molecule corresponding to Estradiol.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:AB4.2,
Isotype:IgG1,
Carrier free:No,
Applications:ELISA, RIA, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:ab116648 shows reactivity with Chemical samples.

Properties and Storage Information:
Form-Liquid, Purification technique-Ion exchange chromatography DEAE-C, Storage buffer-Preservative: 0.05% Sodium azideConstituents: 0.79% Sodium chloride, 0.135% Tripotassium orthophosphate, 0.1% BSA, 0.019% Potassium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Estradiol also known as E2 is a form of estrogen a steroidal hormone and an important player in the reproductive system. Its molecular mass is approximately 272.4 g/mol. Estradiol is mainly expressed in the ovaries but it is also produced in smaller amounts by fat tissue brain and adrenal glands. It acts as a primary female sex hormone binding to estrogen receptors within target tissues to exert its effects.
Biological function summary
Estradiol plays essential roles in regulating the reproductive and menstrual cycles promoting development and maintenance of female secondary sexual characteristics. The hormone functions as part of a larger complex the estrogen receptor complex which alters gene expression after binding. Beyond reproduction estradiol impacts several systems including skeletal cardiovascular and central nervous systems highlighting its diverse biological roles.
Pathways
This hormone functions in the estrogen signaling pathway and the regulation of gene expression. Estradiol interacts with proteins like estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) to influence various gene expression paths. These pathways govern cell proliferation differentiation and apoptosis highlighting the hormone's intricate involvement in cellular processes and its impact on health and disease.
Estradiol levels influence conditions like breast cancer and osteoporosis. Abnormal estradiol production or receptor dysfunction can contribute to estrogen-dependent breast cancer where high levels promote tumor growth by interacting with proteins like ERα. In osteoporosis estradiol deficiencies accelerate bone resorption by the regulation of osteoclast activity illustrating its important role in maintaining bone health.