Abcam, ab117777, Anti-ZNF644 antibody

Size: 100µg
Rabbit Polyclonal ZNF644 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ZNF644 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ZNF644 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q9H582

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab117777 was affinity purified using an epitope specific to ZNF644 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF644 also known as Zinc Finger Protein 644 is a transcription factor with a molecular mass of approximately 145 kDa. It contains multiple C2H2-type zinc finger domains that facilitate binding to specific DNA sequences influencing gene expression. Researchers have found ZNF644 expression predominantly in the brain particularly in the cerebral cortex as well as in other tissues like the liver and kidney. The protein functions in regulating various genes that guide neural development and other essential cellular processes.
Biological function summary
Zinc finger proteins like ZNF644 serve as important regulators of genetic transcription. ZNF644 operates in coordination with other protein complexes to control the expression patterns critical for maintaining cellular homeostasis. The protein aids in modulating several genes involved in neurodevelopment and synaptic functions playing significant roles in the proper formation and functionality of neural circuits. Its ability to influence gene expression patterns contributes to its involvement in broader regulatory networks within the cell.
Pathways
ZNF644 is involved in gene regulatory networks that influence developmental and neuronal pathways. It interacts with other transcription factors and co-regulators like REST (RE1-Silencing Transcription Factor) that modulate neural gene expression during development. ZNF644 plays a role in the mTOR signaling pathway which is critical for cellular growth metabolism and synaptic plasticity. This involvement signifies its contribution to the maintenance of neurological health and development.
Researchers have linked ZNF644 to high myopia and certain neurodevelopmental disorders. Mutations in ZNF644 associate with refractive errors leading to high myopia impacting retinal development and eye function. Additionally the protein interacts with other neurodevelopmental proteins like CTNND2 suggesting a role in mental and cognitive disorders. Further investigation into its mutations and expression patterns could provide insights into the development and progression of these conditions.