Abcam, ab117803, Anti-ZNF687 antibody

Size: 100µg
Rabbit Polyclonal ZNF687 antibody. Suitable for IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ZNF687 aa 100-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ZNF687 aa 100-150. The exact immunogen used to generate this antibody is proprietary information.Q8N1G0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab117803 was affinity purified using an epitope specific to ZNF687 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF687 also known as zinc finger protein 687 is a transcription factor with a known molecular mass of approximately 137 kDa. This protein contains multiple zinc finger motifs that enable its binding to specific DNA sequences regulating the transcription of certain genes. ZNF687 is expressed in various tissues including the brain liver and bone marrow. Its ability to bind DNA is critical for controlling gene expression related to cell proliferation and differentiation.
Biological function summary
ZNF687 functions as a regulatory protein involved in gene expression playing an important role in cellular growth and differentiation. It does not appear to be part of a larger protein complex but acts through binding to specific DNA sequences. The protein helps regulate genes involved in hematopoiesis and neural development suggesting a role in the development and maintenance of these tissues.
Pathways
ZNF687 contributes to gene transcription pathways important for cellular growth and development. It interfaces with signaling pathways such as the MAPK/ERK pathway which is significant for cell proliferation and survival. ZNF687 associates with other transcription factors and its function affects proteins like MYC and FOS which are central to these pathways. By regulating these pathways ZNF687 impacts cellular responses to internal and external stimuli.
ZNF687 is connected to several conditions including osteosarcoma and Paget's disease of bone. Mutations or dysregulation of ZNF687 have been implicated in these diseases potentially through interactions with proteins like SQSTM1 which plays a role in bone remodeling. Research continues to explore ZNF687's contributions to these conditions indicating its relevance in understanding and possibly targeting these diseases.