Abcam, ab118800, Anti-ZZZ3 antibody

Size: 100µg
Rabbit Polyclonal ZZZ3 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ZZZ3 aa 50-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ZZZ3 aa 50-100. The exact immunogen used to generate this antibody is proprietary information.Q8IYH5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab118800 was affinity purified using an epitope specific to ZZZ3 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZZZ3 also known as Zinc Finger ZZ-Type Containing 3 serves as a component of several essential cellular processes. This protein has a molecular mass of approximately 90 kDa. Researchers have identified its expression predominantly in the nucleus across diverse human tissues indicating its widespread functional impact. Mechanically ZZZ3 acts as a transcriptional regulator important for mediating gene expression by interacting with specific DNA sequences.
Biological function summary
ZZZ3 plays a role as part of the ADA2a-containing (ATAC) histone acetyltransferase complex. This complex impacts chromatin remodeling by modifying histone acetylation influencing the accessibility of transcription factors to DNA. The protein's ability to alter chromatin structure makes it significant in regulating gene expression during cell cycle progression and differentiation.
Pathways
ZZZ3 functions prominently within chromatin organization and transcription regulation pathways. It interacts closely with proteins such as GCN5 a histone acetyltransferase to modulate these pathways. Additionally the protein is involved in the transcriptional co-activator role co-operating with various transcription factors to facilitate RNA polymerase II-driven gene transcription.
Altered ZZZ3 function links to conditions like cancer and neurological disorders. It associates with the dysregulation of gene expression observed in these diseases. In cancer ZZZ3 works in conjunction with oncogenes and tumor suppressor genes contributing to tumorigenic processes. Similarly aberrant interaction with proteins involved in neural signaling pathways can implicate ZZZ3 in certain neurological pathologies where it may affect neural development or function.