Abcam, ab119686, Anti-ATP5C1 antibody [2A1AA11]

Size: 100µg
Mouse Monoclonal ATP5C1 antibody. Suitable for Flow Cyt, WB, ICC/IF, IHC-P and reacts with Human, Mouse, Rat, Cow samples. Cited in 7 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:2A1AA11,
Isotype:IgG2b,
Light chain type:kappa,
Carrier free:No,
Reacts with:Mouse, Rat, Cow, Human,
Applications:ICC/IF, Flow Cyt, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Product details:
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Properties and Storage Information:
Form-Liquid, Purification technique-Precipitation Ammonium Sulphate, Purification notes-Purity is near homogeneity as judged by SDS-PAGE. The antibody was produced in vitro using hybridomas grown in serum-free medium, and then concentrated by ammonium sulfate precipitation., Storage buffer-pH: 7.5Preservative: 0.02% Sodium azideConstituents: 99% HEPES buffered saline, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The ATP5C1 protein also known as ATP synthase subunit gamma plays an important role in cellular energy production. This protein has a mass of approximately 55 kDa. It remains primarily expressed in the mitochondria the powerhouse of cells where it forms a part of the ATP synthase complex. ATP5C1 is essential for ATP synthesis a pivotal process for energy production in cells.
Biological function summary
The ATP5C1 protein is an integral component of the F1 sector of the ATP synthase complex. This complex transduces electrochemical energy into ATP which is the main energy carrier in biological systems. ATP5C1 facilitates rotation of the complex’s central stalk enabling energy conversion. It ensures ATP is produced efficiently supporting various cellular processes. ATP5C1 expression levels affect cellular metabolism and energy homeostasis.
Pathways
ATP5C1 holds an important position within oxidative phosphorylation and the mitochondrial electron transport chain. These pathways are vital for ATP production and involve several proteins and enzymes including NADH dehydrogenase cytochrome c oxidase and other ATP synthase subunits. ATP5C1 interacts with these proteins to sustain the flow of electrons coupling it with proton gradients that drive ATP synthesis.
ATP5C1 mutations or malfunctions link to conditions such as mitochondrial diseases and metabolic disorders. For instance alterations in ATP5C1 can affect ATP synthesis efficiency leading to mitochondrial dysfunction. It also associates with neurodegenerative diseases where inefficient energy production exacerbates neuronal degradation. The protein's dysfunction may involve other proteins like ATP5D a fellow subunit within the ATP synthase complex that collaborates in maintaining ATP production.