Abcam, ab119714, Anti-CORO1B antibody

Size: 100µL
Rabbit Polyclonal CORO1B antibody. Suitable for WB, ICC/IF and reacts with Human, Rabbit samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human CORO1B.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rabbit, Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CORO1B. The exact immunogen used to generate this antibody is proprietary information.Q9BR76

Product details:
Do not aliquot.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab119714 was affinity purified using CORO1B (C-terminus) peptide (without carrier)., Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein CORO1B also known as Coronin-1B is an actin-binding protein involved in cellular structure and motility. CORO1B weighs approximately 55 kDa and is part of the coronin family. It is expressed in various tissues with strong expression in brain heart and skeletal muscle. Functionally CORO1B regulates actin cytoskeleton dynamics which is important for processes such as cell migration and maintenance of cell shape.
Biological function summary
Coronin-1B acts to control the remodeling of actin filaments. This protein plays a role in actin cytoskeleton organization and is located typically in cellular regions such as lamellipodia and filopodia. It acts independently but can also form complexes with other proteins like Arp2/3 complex to facilitate actin branching. Through its interactions Coronin-1B modulates the cell's cytoskeletal architecture impacting cell movement and adhesion.
Pathways
Studies connect Coronin-1B to the actin-related protein 2/3 (Arp2/3) complex pathway which influences actin polymerization. Coronin-1B also associates with the Rac1 pathway affecting cell migration and cellular responses to the environment. RAC1 a small GTPase involved in numerous cellular projects often associates with Coronin-1B in regulating actin dynamics. These pathways indicate its significant role in cellular movement and organization.
Studies link Coronin-1B to cancer metastasis due to its regulatory function in cell motility. Overexpression or mutation of Coronin-1B might influence cancer progression by altering cell migration patterns. Additionally Coronin-1B has connections to cardiovascular diseases where disruptions in actin dynamics affect heart muscle function. It often associations with other proteins like Arp2/3 and RAC1 which participate in related pathological processes.