Abcam, ab119779, Anti-Tristetraprolin/TTP antibody [OTI1A2]

Size: 100µL
Mouse Monoclonal Tristetraprolin/TTP antibody. Suitable for IHC-P, WB, Flow Cyt (Intra) and reacts with Human, Mouse, Dog samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ZFP36.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI1A2,
Isotype:IgG2a,
Carrier free:No,
Reacts with:Mouse, Dog, Human,
Applications:WB, IHC-P, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human ZFP36.P26651

Product details:
Clone OTI1A2 (formerly 1A2).

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Purification notes-Purified from cell culture supernatant by affinity chromatography., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Tristetraprolin (TTP) also called ZFP36 is a protein that regulates mRNA stability and decay. It has a molecular mass of approximately 36 kDa. TTP usually resides in the cytoplasm and nucleus of a cell. Many types of tissues especially those involved in immune response express TTP. Researchers have identified TTP as part of a family of CCCH zinc-finger proteins which play key roles in mRNA turnover by binding to AU-rich elements in the 3' untranslated regions of target mRNAs.
Biological function summary
TTP controls the degradation of cytokine mRNAs such as TNF-alpha and GM-CSF by inducing deadenylation and subsequent decay. As part of mRNA degradation complexes TTP recruits enzymes that participate in the deadenylation process ensuring precise regulation of gene expression. This ability to selectively regulate mRNA levels helps balance the production of proteins important for inflammation immune responses and cell growth. Through these processes TTP maintains cellular homeostasis and modulates responses to environmental changes.
Pathways
TTP functions within the anti-inflammatory pathway by modulating cytokine levels and the NF-kappaB signaling pathway which are important for cellular stress responses and immune regulation. It affects these pathways by interacting with several proteins including 14-3-3 that regulate its activity and localization. Another key interaction is with deadenylase complexes like CAF1 which are integral in carrying out mRNA decay. These interactions allow TTP to effectively manage inflammatory responses reinforcing its regulatory role in immune system pathways.
Altered TTP expression or function links to autoimmune diseases and certain cancers. In autoimmune conditions like rheumatoid arthritis reduced TTP levels are associated with an overproduction of inflammatory cytokines. This imbalance leads to chronic inflammation and tissue damage. In cancers especially breast cancer TTP downregulation can contribute to tumor progression by allowing increased expression of mRNAs involved in cell proliferation and survival. Other proteins such as TNF-alpha and IL-6 have been observed to interact closely with TTP in these disease contexts.