Abcam, ab120089, XE-991 dihydrochloride, KCNQ channel blocker; blocks M current

Size: 10mg / 50mg
MW 449.4 Da, Purity >99%. Potent and selective blocker of KCNQ voltage-gated potassium channels. Blocks M current. (IC 50 values are 0.98 μM (M-current), 0.71 μM (KCNQ 2), 0.75 μM (KCNQX 1), >100 μM (Kv1.2) and >43 μM (Kv4.3). Potent pulmonary vasoconstrictor. Cognitive enhancer following oral administration in vivo .
Key facts
CAS number:122955-42-4,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:449.4 Da,
Molecular formula:C26H22Cl2N2O,
PubChem:45073462,
Nature:Synthetic,
Solubility:Soluble in water to 100 mM,
Biochemical name:XE 991 dihydrochloride,
Biological description:Potent and selective blocker of KCNQ voltage-gated potassium channels. Blocks M current. (IC50 values are 0.98 μM (M-current), 0.71 μM (KCNQ 2), 0.75 μM (KCNQX 1), >100 μM (Kv1.2) and >43 μM (Kv4.3). Potent pulmonary vasoconstrictor. Cognitive enhancer following oral administration in vivo.,
Canonical smiles:C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3C2(CC4=CC=NC=C4)CC5=CC=NC=C5.Cl.Cl,
InChi:InChI=1S/C26H20N2O.2ClH/c29-25-21-5-1-3-7-23(21)26(17-19-9-13-27-14-10-19,18-20-11-15-28-16-12-20)24-8-4-2-6-22(24)25;;/h1-16H,17-18H2;2*1H,
InChiKey:WOGWMARIFDNZON-UHFFFAOYSA-N,
IUPAC Name:10,10-bis(pyridin-4-ylmethyl)anthracen-9-one;dihydrochloride

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months