Abcam, ab120132, Ketanserin tartrate, 5-HT2 antagonist

Size: 50mg / 250mg
MW 545.5 Da, Purity >98%. 5-HT2A antagonist. Also shows moderate affinity and selectivity for human 5-HT1Dα over 5-HT1β, and affinity at α1 adrenoceptors. Antihypertensive *in vivo*.
Key facts
CAS number:83846-83-7,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:545.5 Da,
Molecular formula:C26H28FN3O9,
PubChem:135348,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mMSoluble in water to 10 mM,
Biochemical name:Ketanserin tartrate,
Biological description:5-HT2A antagonist. Also shows moderate affinity and selectivity for human 5-HT1Dα over 5-HT1β, and affinity at α1 adrenoceptors. Antihypertensive *in vivo*.,
Canonical smiles:C1CN(CCC1C(=O)C2=CC=C(C=C2)F)CCN3C(=O)C4=CC=CC=C4NC3=O.C(C(C(=O)O)O)(C(=O)O)O,
InChi:InChI=1S/C22H22FN3O3.C4H6O6/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29;5-1(3(7)8)2(6)4(9)10/h1-8,16H,9-14H2,(H,24,29);1-2,5-6H,(H,7,8)(H,9,10),
InChiKey:KMTLTEVOQLMYRS-UHFFFAOYSA-N,
IUPAC Name:2,3-dihydroxybutanedioic acid;3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-1H-quinazoline-2,4-dione

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient, Storage information-The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The target '15-PGDH H-ERG NPSR1' refers to three different proteins that serve distinct functions. 15-PGDH the enzyme 15-hydroxyprostaglandin dehydrogenase plays a role in the catabolism of prostaglandins and has a mass of approximately 29 kDa. It expresses highly in the liver placenta lungs and kidneys. H-ERG or human ether à-go-go-related gene potassium channel is a protein contributing to the cardiac action potential and has a molecular mass of about 134 kDa. It is expressed in the heart and nervous system. NPSR1 known as the Neuropeptide S receptor is a G-protein coupled receptor predominantly located in the central nervous system and the respiratory tract.
Biological function summary
These proteins serve various essential functions. 15-PGDH is responsible for regulating prostaglandin levels which modulate inflammation and cellular differentiation. H-ERG forms the pore of potassium ion channels critical for electrical signaling in the heart therefore preventing arrhythmias. NPSR1 involves signaling related to neuropeptides influencing anxiety and asthma responses. These proteins do not function as part of a single complex but perform distinct roles important for maintaining homeostasis within their respective systems.
Pathways
The protein 15-PGDH functions primarily in the eicosanoid signaling pathway impacting inflammatory responses. It associates with enzymes like cyclooxygenase involved in prostaglandin biosynthesis. H-ERG is part of the cardiac electrical signaling pathway interacting with other ion channels to maintain the heart's rhythmic heartbeat. NPSR1 links to neuropeptide signaling pathways modulating intracellular processes through interactions with proteins like G-protein subunits.
These proteins are linked to specific health issues. 15-PGDH's dysregulation associates with cancer due to its role in controlling anti-inflammatory responses. Alterations in H-ERG can lead to cardiac disorders such as Long QT syndrome an irregular heartbeat condition. In this context it interacts with proteins such as KCNQ1 another cardiac channel protein. Meanwhile imbalances in NPSR1 expression connect with asthma influencing airway responses through interaction with other inflammatory mediators.