Abcam, ab120238, Prazosin hydrochloride, Peripheral alpha adrenoceptor antagonist

Size: 50mg / 250mg
MW 419.9 Da, Purity >99%. Peripheral α 1 and α 2 adrenoceptor antagonist. Orally active vasodilator. Also melatonin MT 3 antagonist.
Key facts
CAS number:19237-84-4,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:419.9 Da,
Molecular formula:C19H22ClN5O4,
PubChem:68546,
Nature:Synthetic,
Solubility:Soluble in DMSO to 25 mMSoluble in ethanol to 5 mM,
Biochemical name:Prazosin hydrochloride,
Biological description:Peripheral α1 and α2 adrenoceptor antagonist. Orally active vasodilator. Also melatonin MT3 antagonist.,
Canonical smiles:COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC=CO4)N)OC.Cl,
InChi:InChI=1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H,
InChiKey:WFXFYZULCQKPIP-UHFFFAOYSA-N,
IUPAC Name:[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone;hydrochloride

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Alpha 1 adrenergic receptor also known as ADRA1 is a G protein-coupled receptor with a mass of approximately 63 kDa. This receptor binds adrenergic agonists and plays a significant role in the sympathetic nervous system. The receptor is widely expressed in various tissues especially in the vascular smooth muscles liver and heart. Cytochrome P450 3A4 or CYP3A4 is one of the most important enzymes in the liver responsible for drug metabolism with a molecular weight of about 57 kDa. TDP1 a DNA repair enzyme is associated with the repair of single-stranded breaks and shows a lesser-known presence in the cell nucleus. Geminin functions in the regulation of DNA replication and exists in the nucleus whereas RAD54 involves with homologous recombination during DNA double-strand break repair localized primarily in the nucleus. DNA Polymerase Kappa also known as POLK participates in the bypass of DNA lesions during DNA replication and predominantly resides in the nucleus. Finally ROR gamma an important nuclear receptor modulates transcriptional activities and appears highly in immune cells and organs like the thymus.
Biological function summary
Proteins like alpha 1 adrenergic receptors initiate cellular responses by increasing intracellular calcium. They engage in vasoconstriction and cardiac contraction mechanisms. Cytochrome P450 3A4 contributes significantly to steroid metabolism and detoxification of exogenous substances. TDP1 interacts within a complex to repair DNA breaks caused by topoisomerase I inhibitors. Geminin regulates cell cycle by inhibiting DNA replication initiation. RAD54 acts in coordination with RAD51 in homologous recombination repair pathways. DNA Polymerase Kappa serves as a translesion synthesis polymerase maintaining DNA replication over lesions. ROR gamma oversees important immune response processes and differentiation of T helper cells.
Pathways
The functions of alpha 1 adrenergic receptors fall under adrenergic signaling and smooth muscle contraction pathways. They interact with other components such as beta adrenergic receptors influencing systemic vascular resistance. CYP3A4 plays a vital role in the metabolic degradation pathway of various pharmaceuticals and endobiotics. Pathways involving TDP1 relate to the repair via tyrosyl-DNA phosphodiesterase activity in response to DNA damage. Geminin influences the cell cycle by controlling the licensing of DNA replication. RAD54 participates within DNA repair pathways and collaborates with RAD52. DNA Polymerase Kappa engages in DNA damage tolerance pathways critical during cellular replication stress. ROR gamma drivers transcriptional networks in immune cell differentiation and function involving similar networks as ROR alpha.
Alpha 1 adrenergic receptors relate to hypertension and cardiac hypertrophy where they modulate vascular tone and cardiac workload. Upon impaired activity CYP3A4 associates with drug-drug interactions and adverse drug reactions. TDP1 deficiencies have connections to neurological disorders mirroring defects seen with topoisomerase I. Geminin dysfunction could lead to uncontrolled replication associated with cancerous processes. Impaired RAD54 activity contributes to genomic instability often linked with related proteins like BRCA1 in cancer predisposition. Altered DNA Polymerase Kappa functionality associates with mutagenesis potentially leading to carcinogenesis. ROR gamma dysregulation connects to autoimmunity disorders such as lupus being closely related to cytokine production pathways.