Abcam, ab120243, LY 294002, PI3-kinase inhibitor

Size: 1mg / 5mg / 25mg
MW 307.3 Da, Purity >99%. A highly selective inhibitor of phosphatidylinositol 3-kinase (IC 50 = 1.4 μM). Selective over a range of other kinases including protein kinase C, protein kinase A, MAPK and PI4- kinase (IC 50 > 50 μM).
Key facts
CAS number:154447-36-6,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:307.3 Da,
Molecular formula:C19H17NO3,
PubChem:3973,
Nature:Synthetic,
Solubility:Soluble in DMSO to 25 mM and in ethanol to 5 mM,
Biochemical name:2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one,
Biological description:A highly selective inhibitor of phosphatidylinositol 3-kinase (IC50 = 1.4 μM). Selective over a range of other kinases including protein kinase C, protein kinase A, MAPK and PI4- kinase (IC50 > 50 μM).,
Canonical smiles:C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4,
InChi:InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2,
InChiKey:CZQHHVNHHHRRDU-UHFFFAOYSA-N,
IUPAC Name:2-morpholin-4-yl-8-phenylchromen-4-one

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The PI3 kinase family is a group of enzymes involved in key cellular functions and it includes members like PI3 Kinase p110 beta p110 delta PI3K p85 alpha Class 2A (Cpk) and the catalytic subunit gamma (PI3K-gamma) as well as PIK3C2B. These kinases belong to the phosphoinositide 3-kinase (PI3K) family which are lipid kinases known for their role in phosphorylation of the 3' hydroxyl group of the inositol ring of phosphoinositides. They vary in mass for instance PIK3C2B has a mass of approximately 200 kDa. These kinases express widely across tissues with each subtype favoring certain tissues—for example PI3K-gamma is abundant in leukocytes.
Biological function summary
PI3 kinase enzymes regulate various cellular functions such as growth proliferation and survival. They often function as part of a complex like the PI3K heterodimer which includes regulatory subunits like p85 alpha. The enzymes are important for cellular processes that involve signal transduction from cell surface receptors to downstream effectors resulting in metabolic and gene expression changes. These kinases interact with other signaling proteins to exert influence on the cell’s behavior in response to external stimuli often through the generation of second messengers.
Pathways
PI3 kinase plays a significant role in the PI3K/AKT signaling pathway a critical pathway for regulating the cell cycle. This pathway includes key proteins like AKT a serine/threonine-specific protein kinase also known as protein kinase B (PKB). PI3 kinase also interacts with the mTOR (mechanistic target of rapamycin) pathway which influences cell growth and metabolism in response to nutrients and other growth signals. PI3K inhibitors like LY294002 and its hydrochloride form target this pathway to modulate signaling and offer therapeutic potential.
PI3 kinase is linked to a variety of conditions notably cancer and diabetes due to its role in cell growth and survival. Dysregulation of the PI3K/AKT pathway often leads to oncogenesis and abnormalities in this pathway relate closely with mutated proteins such as PIK3CA PTEN and AKT in various cancers. In diabetes altered PI3K signaling contributes to insulin resistance affecting glucose metabolism. The relationship of PI3 kinase with these proteins in disease contexts highlights its promise as a therapeutic target for PI3K inhibitors.