Abcam, ab120396, DPCPX, A1 antagonist

Size: 25mg / 100mg
MW 304.39 Da, Purity >99%. Potent A1antagonist (Ki = 0.45 nM). Also exhibits antagonism at A2B receptors (pA2 = 7.16, for human A2B expressed in CHO cells).
Key facts
CAS number:102146-07-6,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:304.39 Da,
Molecular formula:C16H24N4O2,
PubChem:1329,
Nature:Synthetic,
Solubility:Soluble in ethanol to 10 mMSoluble in DMSO to 5 mM,
Biochemical name:8-Cyclopentyl-1,3-dipropylxanthine,
Biological description:Potent A1antagonist (Ki = 0.45 nM). Also exhibits antagonism at A2B receptors (pA2 = 7.16, for human A2B expressed in CHO cells).,
Canonical smiles:CCCN1C2=C(C(=O)N(C1=O)CCC)NC(=N2)C3CCCC3,
InChi:InChI=1S/C16H24N4O2/c1-3-9-19-14-12(15(21)20(10-4-2)16(19)22)17-13(18-14)11-7-5-6-8-11/h11H,3-10H2,1-2H3,(H,17,18),
InChiKey:FFBDFADSZUINTG-UHFFFAOYSA-N,
IUPAC Name:8-cyclopentyl-1,3-dipropyl-7H-purine-2,6-dione

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient, Storage information-The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Adenosine A1 Receptor also known as ADORA1 and the Adenosine A2b Receptor known as ADORA2B are important protein receptors in the body. Mechanically they belong to the G protein-coupled receptor (GPCR) family involved in a variety of cellular responses to adenosine. The A1 receptor generally inhibits adenylate cyclase activity whereas A2b receptor stimulates it. Both receptors have a substantial presence in the central nervous system as well as in the heart and kidneys. The approximate mass of the A1 receptor is 37 kDa while A2b receptor is around 36 kDa.
Biological function summary
The adenosine receptors A1 and A2b regulate diverse physiological processes. They do not form part of larger protein complexes but act mainly by interacting with G proteins to modulate intracellular signaling pathways. The A1 receptor typically influences neurotransmitter release heart rate modulation and renal blood flow while A2b receptor has roles in inflammatory responses and vascular relaxation. These receptors are important for fine-tuning many cellular functions and systemic processes.
Pathways
Both the Adenosine A1 and A2b receptors are central to the adenosine signaling pathway and the cAMP pathway. They interact with proteins like adenylate cyclase and phospholipase C in these pathways. The A1 receptor's inhibition of adenylate cyclase leads to reduced cyclic AMP generation while the A2b receptor's stimulation increases cAMP levels. This affects downstream pathways including protein kinase A (PKA) and extracellular signal-regulated kinases (ERK) which play parts in various cellular functions and responses.
Adenosine A1 and A2b receptors have been linked to conditions such as cardiovascular diseases and asthma. The A1 receptor is associated with ischemic conditions in the heart where its modulation might protect against cardiac damage. In contrast the A2b receptor has a known connection to asthma as it affects inflammatory processes in airway tissues. These receptors interact with proteins like phospholipase C and adenylate cyclase which mediate significant responses in these disorders. Understanding these interactions helps in developing therapeutic strategies including the use of A1 antagonists like DPCPX or other chemical antagonists specific to these receptors.