Abcam, ab120521, Pindolol, 5-HT1A and 5-HT1B receptor antagonist

Size: 100mg
MW 248.32 Da, Purity >99%. 5-HT1A and 5-HT1B receptor antagonist (Ki and IC50 values are 8.9 and 6.8 nM at 5-HT1A and 5-HT1B receptors, respectively). Partial β3 adrenoceptor agonist (pEC50 = 5.11). Accelerates antidepressant effects of selective serotonin reuptake inhibitors (SSRIs).
Key facts
CAS number:13523-86-9,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:248.32 Da,
Molecular formula:C14H20N2O2,
PubChem:4828,
Nature:Synthetic,
Solubility:Soluble in DMSO to 50 mMSoluble in ethanol to 25 mM (with heating),
Biochemical name:Pindolol,
Biological description:5-HT1A and 5-HT1B receptor antagonist (Ki and IC50 values are 8.9 and 6.8 nM at 5-HT1A and 5-HT1B receptors, respectively). Partial β3 adrenoceptor agonist (pEC50 = 5.11). Accelerates antidepressant effects of selective serotonin reuptake inhibitors (SSRIs).,
Canonical smiles:CC(C)NCC(COC1=CC=CC2=C1C=CN2)O,
InChi:InChI=1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3,
InChiKey:JZQKKSLKJUAGIC-UHFFFAOYSA-N,
IUPAC Name:1-(1H-indol-4-yloxy)-3-(propan-2-ylamino)propan-2-ol

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient, Storage information-The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The targets beta 1 Adrenergic Receptor beta 2 Adrenergic Receptor and beta 3 Adrenergic Receptor are G protein-coupled receptors (GPCRs) recognized for modulating heart rate and muscle relaxation. Beta 1 and beta 2 receptors typically express in cardiac and pulmonary tissues with a mass of approximately 46 kDa each. The beta 3 Adrenergic Receptor however is more prevalent in adipose tissue and is involved in energy balance. The 5-HT receptors including 5-HT1B 5-HT1D 5-HT2A 5-HT2B and 5-HT2C interact with serotonin to influence mood cognition and perception. SLC22A1/OCT1 is an organic cation transporter present in the liver playing a role in drug clearance. Galactosidase alpha known for its lysosomal function with a role in glycosphingolipid metabolism expresses in various tissues notably within the central nervous system.
Biological function summary
These receptors and transporters modulate significant cellular processes. The adrenergic receptors regulate the sympathetic nervous system facilitating responses like vasodilation and bronchodilation. 5-HT receptors manage neurotransmitter pathways impacting mood and sensory processing. The SLC22A1/OCT1 transporter is important for drug absorption and metabolism affecting pharmacokinetics. Galactosidase alpha functions enzymatically within the lysosome as part of a larger enzyme complex that breaks down glycolipids.
Pathways
The adrenergic receptors engage in the adrenergic signaling pathway interacting with kinases and enzymes to modulate cardiovascular functions. The 5-HT receptors are integral to the serotonin signaling pathway influencing neurological and behavioral outcomes. The SLC22A1/OCT1 operates within the hepatic clearance pathways affecting the metabolism of various therapeutic compounds. The function of Galactosidase alpha ties into the lysosomal degradation pathway connected with enzymes like ceramide trihexosidase.
The adrenergic receptors associate with cardiovascular diseases such as hypertension and heart failure often targeted by drugs like pindolol for therapeutic management. Dysregulation of 5-HT receptors links to psychiatric disorders including anxiety and depression as these receptors modulate serotonin’s impact on the brain. Deficiencies in Galactosidase alpha are known to cause Fabry disease a lysosomal storage disorder affecting multiple organs. Pindolol a non-selective beta-blocker interacts with these adrenergic systems offering insights into therapeutic strategies for managing hypertension and anxiety-related disorders.