Abcam, ab120633, DAPT, gamma-Secretase inhibitor

Size: 10mg / 50mg
γ-Secretase inhibitor. Inhibits Notch signalling in vitro. Inhibits total Aβ and Aβ42 production in human primary cultures (IC50 values are 115 and 200 nM, respectively) with no effect on APPα and APPβ levels. MW 432.5. - Blood-brain barrier (BBB) permeable - 3D Growth matrix component and component of cerebral organoid differentiation media - Available in different sizes to fit your experimental needs
Key facts
CAS number:208255-80-5,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:432.5 Da,
Molecular formula:C23H26F2N2O4,
PubChem:5311272,
Nature:Synthetic,
Biochemical name:Dapt,
Biological description:γ-Secretase inhibitor. Inhibits Notch signalling in vitro. Inhibits total Aβ and Aβ42 production in human primary cultures (IC50 values are 115 and 200 nM, respectively) with no effect on APPα and APPβ levels. Blood-brain barrier permeable. 3D Growth matrix component and component of cerebral organoid differentiation media.,
Canonical smiles:CC(C(=O)NC(C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F,
Isomeric smiles:C[C@@H](C(=O)N[C@@H](C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F,
InChi:InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1,
InChiKey:DWJXYEABWRJFSP-XOBRGWDASA-N,
IUPAC Name:tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate

Product details:
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Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-The product can be stored for up to 12 months