Abcam, ab120654, Betulinic acid, TGR5 agonist

Size: 10mg / 50mg
MW 456.7 Da. Triterpenoid with various biological activities. Apoptosis inducer, with anticancer properties. Also shows anti-HIV, antimalarial and anti-inflammatory activity. TGR5 agonist (EC 50 = 1.04 μM).
Key facts
CAS number:472-15-1,
Form:SolidSee storage information,
Molecular weight:456.7 Da,
Molecular formula:C30H48O3,
PubChem:64971,
Nature:Synthetic,
Solubility:Soluble in DMSO to 50 mM (with warming),
Biochemical name:Betulinic acid,
Biological description:Triterpenoid with various biological activities. Apoptosis inducer, with anticancer properties. Also shows anti-HIV, antimalarial and anti-inflammatory activity. TGR5 agonist (EC50 = 1.04 μM).,
Canonical smiles:CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)C(=O)O,
Isomeric smiles:CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)C(=O)O,
InChi:InChI=1S/C30H48O3/c1-18(2)19-10-15-30(25(32)33)17-16-28(6)20(24(19)30)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h19-24,31H,1,8-17H2,2-7H3,(H,32,33)/t19-,20+,21-,22+,23-,24+,27-,28+,29+,30-/m0/s1,
InChiKey:QGJZLNKBHJESQX-FZFNOLFKSA-N,
IUPAC Name:(1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DNA polymerase beta often referred to as Pol β plays an essential role in DNA repair specifically base excision repair. It has a molecular mass of approximately 39 kDa and is widely expressed in various tissues. Interferon gamma also known as IFNγ functions in the immune system to activate macrophages and is about 20 kDa in size. Liver X receptor alpha (LXRα) is a nuclear receptor that influences cholesterol homeostasis and is expressed predominantly in liver adipose tissue and macrophages. The protein UBE2I also known as UBC9 functions as an E2 SUMO-conjugating enzyme in the process of sumoylation with a size of about 18 kDa and is found in most cell types.
Biological function summary
DNA polymerase beta contributes to the maintenance of genome integrity by filling in small gaps left after DNA repair. It works as part of a repair complex ensuring proper function and stability of genetic information. Interferon gamma plays a critical role in immune response regulation and cellular communication. LXRα is involved in lipid metabolism and serves as an important regulator for genes managing cholesterol and fatty acid metabolism. UBE2I/UBC9 is essential for protein post-translational modification influencing protein activity stability and localization.
Pathways
DNA polymerase beta is significantly integrated within the base excision repair pathway which is important for correcting DNA damage from oxidative stress alongside proteins like AP endonuclease. Interferon gamma is a major participant in the JAK-STAT signaling pathway interacting with proteins such as STAT1 to mediate immune responses. LXRα is part of the lipid metabolism pathway closely related to ATP-binding cassette transporters. UBE2I is implicated in sumoylation pathways affecting pathways for protein degradation and cellular response to stress.
DNA polymerase beta mutations or dysregulation can lead to cancer due to compromised DNA repair mechanisms; it is often studied in relation to BRCA1 protein dysfunction in breast cancer. Interferon gamma is critical in autoimmune and inflammatory diseases such as multiple sclerosis involving abnormal immune responses potentially influenced by GPCR TGR5 interactions. LXRα has been linked to atherosclerosis due to its role in lipid homeostasis interacting with proteins like apolipoprotein E. Aberrant sumoylation via UBE2I can contribute to neurodegenerative disorders with proteins like tau becoming improperly modified.